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Adjuvant induced Arthritis (AIA) Model


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Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disease which affected a lot of people. RA is characterized by synovial joints and subsequent progressive erosive destruction of articular cartilage causing progressive damage to the musculoskeletal system. Nowadays, it is becoming a serious problem threatening people’s health and life. Patients lost the physical function and suffer from joint pain. Thus, it is crucial to find an advanced treatment on RA.

Animal models are widely used in RA research. The most common models include CIA model, CAIA model and AIA model. Among different models, AIA model is known for its reliability and well-understanding. It is mostly used for evaluating potential treatment of RA and other preclinical or clinical investigations. At Creative Animodel, we offer the best and most reliable AIA models for your research.

AIA model was induced by inoculation of the rats with Freund’s complete adjuvant (FCA). Briefly, on day 0, animals were anesthetized with a mixture of ketamine and xylazine and then injected with CFA at the base of the tail or in one of the foot pads. Hind paw swelling would be monitored from day 9 to 15. After 12 days, adjuvant arthritis rats are relatively immobile due to severity of paw swelling. To assess the disease, caliper measurements of ankle joint width are done every two days until day 15, and other arthritis score is measured in daily basis (As shown in Figures). Additionally, the induced arthritis exhibits the same clinical, histological and immunological features with the human rheumatoid arthritis including increase of pro-inflammatory cytokines such as TNF-α, IL-6, erosion of bones, and pannus formation.

Adjuvant induced arthritis (AIA) model

Creative Animodel also provides various preclinical services which includes, but not limited to:

  • • Clinical Score of arthritis assessment
  • • Body weight measurement
  • • Immunohistochemically evaluation of the arthritis pathology in joints
  • • Evaluation of ankle and paw joint swelling
  • • Assessment of major immune factors such as IL-1, TNF-α
  • • Flow cytometric analysis of the inflammatory cells
  • • PK blood collections

As one of the best vendor of animal models in the world, Creative Animodel is dedicated to create the best and most appropriate animal models of rheumatoid arthritis for our customers. We offer CIA, CAIA and AIA arthritis models and other customized animal models for your research. Moreover, we provide regular and customized preclinical and clinical service to meet all your specific needs.

Reference
Zhi-cheng Zhang, Shui-juan Zhang, Bo Jin, et al., “Ciclamilast Ameliorates Adjuvant-Induced Arthritis in a Rat Model,” BioMed Research International, vol. 2015, Article ID 786104, 11 pages, 2015. doi:10.1155/2015/786104

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-372-1052    Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-207-097-1828

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