Animal Models of Blood Cancer
The urgent need for improving patient survival rates provides the impetus to employ animal as models for blood cancer researches. The comparative living system of these animal models allows researchers to discover the underlying basis of how and why cancers arise, as well as the mechanism of primary tumor metastasis. In order to contribute to a better understanding in blood cancer biology and therapeutic strategies, Creative Animodel offers comprehensive and state-of-the-art animal resources for high-impact blood cancer researches. These models are generated by genetic engineering, graft transplantation, viral induction and chemical induction. Our exceptional team of scientists regularly designs and performs most valuable and widely used animal models to study human blood cancer.
Figure 1: Generation of tumor
Available types of blood cancer
● Myelodysplastic syndrome (MDS)
● Myeloproliferative neoplasms (MPN)
● Waldenstrom's macroglobulinaemia
Approaches to generate cancer models
● Cancer-related genes are altered in animals to develop spontaneous tumors which have similar properties of these generated in human.
● Animals are exposed to some environmental factors such as chemicals or radiation to induce tumors.
Available species as blood cancer models
Use of mice in blood cancer research
● Genetically engineered mouse models
● Inbred mice
● Transplantation models
● Carcinogen-induced and spontaneous models
Figure 2: Use of mice to generate blood cancer
Use of Zebrafish in Blood Cancer Research
● Cancer-related developmental phenotypes
・Cell cycle and genomic instability
・Stem or progenitor specification programmes
・ Developmental effects of transplanted human cancer cells
・ Chemical and genetic screens
● Cancer imaging
・In vivo imaging of cancer initiation and early progression
・Embryo-adult cell type transitions
・Transplantation of human cells
● Adult cancer models
・Transgenic-, mutagen- and transposon-based penetrant cancers
・Genetic modifier screens
・In vivo imaging of cancer progression and metastasis
Creative Animodel has successfully created several mouse models to develop blood cancer especially leukemia due to their similar genetic alterations in human leukemia. They can help to understand the disease development by identifying pre-malignant changes in the blood cells of theirs. We also have advanced zebrafish facilities and comprehensive experience in generating genetically engineering zebrafish to better model blood cancer and to allow the screening of candidate drugs. Coupled with prestigious partners and professional expertise, Creative Animodel aims to provide clients with best customized services at highly competitive prices.