Body Composition Analysis of Obesity
Obesity is a condition of pandemic proportions in the modern world. A myriad of conditions ranging from cardiovascular disease, type-2 diabetes, cancer, and even depression have been linked to obesity. Research into the mechanisms and treatment of obesity is an ongoing area of interest to many in the pharmaceutical and academic communities. After applying potential anti-obesity drugs, body composition analysis can be used to rule out non-specific decreases in water (dehydration) and/or protein content (muscle wasting or cachexia) which can be harmful from reduce body weight by producing a clinically-beneficial selective loss of fat.
Creative Animodel offers up-to-date facility and medical equipment for your obesity study. Our experienced and well-trained experts will work closely with you on body composition analysis for your obesity mechanism investigation or anti-obesity treatment development.
Dual-energy X-ray absorptiometry (DEXA)
DEXA scans are used primarily to evaluate bone mineral density. DEXA scans can also be used to measure total body composition and fat content with a high degree of accuracy comparable to hydrostatic weighing with a few important caveats.
✓ Fat mass (%) and fat mass (g)
✓ Total tissue mass (g)
✓ Lean mass (g)
✓ Bone mineral density (g/cm2)
✓ Bone mineral content (g)
✓ Can be performed in live animals to provide longitudinal measurements of bone and tissue composition
✓ Can be performed throughout chronic studies
✓ Quicker and cheaper than conventional body composition analysis
Conventional body composition analysis
After animal are sacrificed, conventional body composition analysis can be performed to rule out non-specific weight-loss.
Gold-standard chemical analysis in rats and mice:
✓ Carcass fat (Soxhlet), water (freeze drying), protein (Kjeldahl) and ash (furnace)
✓ Organ and faecal analyses
✓ Calibration and validation of DEXA and MRI machines
✓ More precise than DEXA/MRI and also gives an additional measure of bone mass (ash)
Preclinical Magnetic Resonance Imaging (MRI)
MRI is body composition analyzers for live subjects, measuring whole body fat, lean, free water, and total water masses in live animals. With the high precision and accuracy of the measurements carried out by our MRI-based technology, we combine the simplicity of use, the short scan times, and the comfort of animals which need not be restrained or anesthetized.
✓ Live subjects, no anesthesia required, this reduces the impact which anesthesia may have on the research subject.
✓ No radiation or toxicity issues
✓ Regular and repeated measurement over time have no side effects.
✓ Fast and easy
✓ Fat and lean are independently measured
✓ Affordable, comfortable
Creative Animodel provides comprehensive services for body composition analysis, including DEXA, Conventional body composition analysis and MRI. Our one-step services including model selection, experimental design and consultation, statistical analysis by a qualified statistician, fully audited data pack and report written.