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Dextran Sulfate Sodium (DSS)-Induced Colitis Model


Creative Animodel is one of the top companies providing the most comprehensive service for developing animal models of Inflammatory Bowel Disease (IBD) including chronic inflammation as well as acute inflammation. We offer the best service from model selection, model creation to study design, experimental analysis and data collection.

Dextran sodium sulfate (DSS) is a sulfated polysaccharide with anticoagulant properties to induce colitis. It is believed that DSS is directly toxic to gut epithelial cells of the basal crypts and thus harm the integrity of the mucosal barrier. The clinical observation of DSS treated animals are very similar to human IBD pathologies. The symptoms include weight loss, shorten of intestine and villus, diarrhea, and rectal bleeding. Hence, such a model is the most widely used mouse model for investigation of IBD. It has been proved that DSS-induced mice model is particularly appropriate for study of contribution of innate immune mechanisms of colitis and it is useful in study of epithelial repair mechanisms. By using different cycles and approaches to treat the mice, we could obtain acute colitis model or chronic colitis model. 1

DSS-induced mice colitis

Figure 1 DSS-induced mice colitis 2

Creative Animodel provides the DSS-induced acute and chronic colitis animal models. We have experienced experts and scientists who has worked in this area for years and really understand this field. They would work closely with you to provide a one-stop service from model selection, model creation to inflammation assessment and preclinical drug efficacy evaluation. We offer the strategy and experimental design that best fit your needs and herein to accelerate the speed to achieve your research goals.

Creative Animodel also provides various preclinical service for IBD, which includes, but not limited to:

  • • Assessment of Inflammation score
  • • PK/PD blood collection
  • • Body weight measurement
  • • Gut immunohistochemically images
  • • MPO (Myeloperoxidase) activity assessment
  • • Assessment of pro-inflammatory cytokines including IL-1β, IL-6, IFN-γ, TNF-α
  • • Endoscopy imaging
  • • Analyses of inflammation related miRNA (miRNA qPCR, miRNA microArray)

Selected preclinical service

Figure 2 Selected preclinical service3

As thousands and thousands are suffering from inflammatory bowel disease, Creative Animodel is dedicated to create the most suitable animal models for IBD research to facilitate the development of potential treatments. We will work closely with you on every step and be your best assistance on your research against IBD. We are looking forward to cooperating with you and your team.

Reference
1     Wirtz, S. & Neurath, M. F. Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev 59, 1073-1083, doi:S0169-409X(07)00175-5 [pii]10.1016/j.addr.2007.07.003 (2007).
2     Chassaing, B., Aitken, J. D., Malleshappa, M. & Vijay-Kumar, M. Dextran sulfate sodium (DSS)-induced colitis in mice. Curr Protoc Immunol 104, Unit 15 25, doi:10.1002/0471142735.im1525s104 (2014).
3     Kim, J. J., Shajib, M. S., Manocha, M. M. & Khan, W. I. Investigating intestinal inflammation in DSS-induced model of IBD. J Vis Exp, doi:10.3791/36783678 [pii] (2012).

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-372-1052    Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-207-097-1828

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