Knockdown Services


RNA interference has become a widely used approach to perform gene knockdown experiments in cell cultures and more recently transgenic animals. It has developed into a routine method to assess gene function in a fast and easy manner. Since 2008, Creative Animodel's scientists have generated more than 200 RNAi models for innovative biomedical researchers. These RNAi models allow researchers to induce and reverse gene knockdown in transgenic mice at selected time points in vivo.

We have developed RNAi-mediated gene knockdown mice by:

Silencing lentiviral vectors and adenoviral vectors

Transgenic mice can be generated rapidly by transduction of early embryos with lentiviral silencing vectors and adenoviral vectors, resulting in mice with down regulated target genes. These methodologies offer the possibility of large-scale generation of knockdown transgenic mice for functional genomic studies and enable the production of transgenic mice in 7 weeks.

Silencing lentiviral vectors and adenoviral vectors

Cre/loxP system as an activate RNAi in a time- and tissue-dependent manner

Single-copy RNAi constructs are placed into the Rosa26 locus of ES cells by recombinase-mediated cassette exchange and transmitted through the germline of chimaeric mice. The site-specific insertion of single-copy shRNA vectors allows the expedite and reproducible production of knockdown mice and provides an easy and fast approach to assess gene function in vivo.

Cre/loxP system as an activate RNAi in a time- and tissue-dependent manner

Creative Animodel's proprietary RNAi technology enables you to induce and reverse ubiquitous gene knockdown in mice at selected points in time! Contact us!

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Company Address

USA
45-1 Ramsey Road, Shirley,
NY 11967, USA
Tel: + 1-631-372-1052
Fax: + 1-631-614-7828

Europe
Tel: + 44-207-097-1828

Email:
Website: www.creative-animodel.com



45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-372-1052    Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-207-097-1828

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