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Subcutaneous, Orthotopic & Metastatic Xenografts


Creative Animodel has established more than 300 subcutaneous, 40 orthotopic and up-to-date metastatic xenograft models of solid tumors to support your preclinical drug efficiency tests, which involve the following tumor types but are not limited to: brain cancer, breast cancer, bladder cancer, bone cancer, cervical carcinoma, colorectal cancer, epidermoid carcinoma, gastric carcinoma, glioma, head and neck, liver cancer, lung cancer, melanoma, mesothelioma, nasopharyngeal carcinoma, neuroblastoma, ovarian cancer, pancreatic cancer, prostate cancer, renal carcinoma, sarcoma, skin cancer, thyroid cancer etc.

Subcutaneous, Orthotopic & Metastatic Xenografts Regarding to the fact that tumor cells are implanted directly into the origin organ, orthotopic tumor models are considered more clinically relevant and better predictive than standard subcutaneous xenografts. Our orthotopic tumor models includes renal sub-capsule orthotopic model, intracranial orthotopic model, intrasplenic hepatic colonization model (available for assessment of tumor development in a hepatic environment), and orthotopic breast tumor model, which allow a more representative picture of tumor growth and response to therapy scenario.

Except for the xenograft models mentioned above, targeting the most significant problem in the field of cancer, metastatic models are essential for broader understanding of the biology of metastases, of which characterization requires complex experimental systems. Creative Animodel is currently available for triple negative breast cancer, colorectal cancer metastasis models as well as a systemic distribution model by intracardiac injection of tumor cells. These animals develop multiple metastases throughout the body.

Fig.1 Xenograft models of solid tumor supplied by Creative Animodel.

SUBCUTANEOUS XENOGRAFTS CELL LINES PDX
Brain Cancer LN-229, SF-295, SK-N-AS, U87 MG, U251 Available
Breast Cancer 2LMP, 4T1, Bcap-37, BT20, BT474, DU4475, EMT6, HCC-70, HCC-1806, HCC-1954, JIMT-1, KPL-4, MCF-7, MCF-7-luc, MDA-MB-157, MDA-MB-231, MDA-MB-231-luc, MDA-MB-453, MDA-MB-468, Mx-1, SUM159, ZR-75-1, ZR-75-30 Available
Bladder Cancer HT-1197, HT-1376, RT4, SCaBER, SW780, 5637, BFTC905,T24 Available
Bone Cancer U-2 OS  
Cervical Carcinoma AN3 CA, ECC-1, HEC-1-A, ME-180,  MFE-280, Hela, Hela-luc, KB-3-1 Available
Colorectal Cancer CL-34, COLO 201, COLO 205, COLO 320 DM, CT-26, CW-2, DLD-1, HCT-15, HCT-8, HT-29, HT-29-luc, HCT 116, HCT116 P53 K0(-/-), KM12, LoVo, LS-174T, LS-180, LS411N, LS1034, MC38, MC38-CEA, NCI-H716, RKO, SW48, SW403, SW480, SW620, SW837, WiDr Available
Epidermoid Carcinoma A-431 -
Gastric Carcinoma AGS, AGS-luc, BGC-823, HGC-27, Hs746T, MGC-803, MKN-1, MKN-28, MKN-45, MKN-45-luc, NCI-N87, NUGC-4, NUGC-4-luc, SCH, SGC-7901, SNU-5, SNU-16, SNU-16-luc, Hs 746T Available
Glioma LN-229, U-87 MG, U-87 MG-luc -
Head and neck FaDu, KB Available
Liver cancer Bel-7402, HCCLM3, HCCLM3-luc, Hep3B2.1-7, Hep3B, Hep3B-luc, HepG 2, HepG 2-luc, HuH-7, PLC/PRF/5, SNU-398, QGY-7703, SK-HEP-1, SMMC-7721 Available
Lung Cancer 95-D, A-427, A549, A549-luc, Calu-1, Calu-3, Calu-6, DMS114, H69, H82, H211, H510, H526, H1299, H1975, H226, H292, H2171, H358, H460, H520, H522, H647, H727, H810, H1650, H1792, H2009, H2030, H2228, H358, HCC-44, HCC-827, KLN205, LL/2, LLC1, MSTO-211H, NCl-H69, NCl-H146, NCl-H209, NCI-H226, NCI-H446, NCI-H460, NCI-H466, NCI-H520, NCI-H522, NCI-H526, NCl-H720, NCl-H1155, NCI-H1688, NCl-H1770, NCI-H1781, NCI-H1975,  NCI-H1975-luc, NCl-H2106, NCI-H2122, NCI-H2126, NCI-H2228, PC-10, QG-56, SHP-77, SK-MES-1, SW1573 Available
Melanoma A2058, A375, A375-luc, B16, C32, HMCB, IGR-37, MDA-MB-435s, SK-MEL-5, SK-MEL-30 Available
Mesothelioma MSTO-211H -
Nasopharyngeal Carcinoma S18, S26 -
Neuroblastoma SK-N-MC -
Ovarian Cancer A2780, A2780l-luc, ES-2, HO-8910PM, PA-1, IGR0V1, OVCAR-3, OVCAR-5, SK-OV-3, TOV-21G Available
Pancreatic Cancer AsPC-1, BxPc-3, BxPc-3-luc, Capan-1, Capan-2, CFPAC-1, HPAC, HPAF II, KP4, MIA, MIA-luc, PaCa-2, PaCa-2-luc, PANC-1 Available
Prostate Cancer 22Rv.1, CL-1, DU 145, LNCaP clone FGC, PC3, PC-3M-luc Available
Renal Carcinoma A498, ACHN,Caki-1,Caki-2, 786-O, 786-O-luc, G-401, G-402, OS-RC-2, RENCA Available
Sarcoma HT-1080, MG-63, SJSA-1, S-180 Available
Skin Cancer A-431, A375, A2058, SK-MEL-3, Clone M3 -
Thyroid Cancer 8505C, FTC-238 -
ORTHOTOPIC XENOGRAFTS CELL LINES  
Breast Cancer 4T1-Luc, BT474, HCC-1954, KPL-4, MCF-7,MCF-7-Luc, MDA-MB-231,  MDA-MB-231-Luc, MX-1, MDA-MB-468, MDA-MB-231, MDA-MB-453, MDA-MB-157 Available
Cervical Cancer Hela-Luc Available
Colon Cancer HT-29-Luc,Ct26wt,HCT-116 Available
Gastric Cancer MKN-45-Luc, NUGC-4-Luc, SNU-16-Luc, AGS-Luc Available
Glioblastoma U87-MG-Luc,LN-229 -
Hepatocellular carcinoma HepG2-luc, Hep3B-Luc, HCCLM3-Luc Available
Intracranial Orthotopic Model U87MG -
Lung carcinoma A549-luc,CL1-5,NCl-H1975-Luc Available
Melanoma A375 Available
Ovarian Cancer A2780-Luc Available
Pancreatic Cancer AsPC1,BxPC-3-Luc,MiA-PaCa2 Available
Prostate Cancer PC-3M-Luc,LNCaP (Z2)* Available
Renal Sub-Capsule Orthotopic Model of Cancer 786-O,786-O-Luc,Caki-1,RENCA Available
METASTASIS XENOGRAFTS CELL LINES  
Breast cancer Metastasis MDA-MB-231-luc -
Colorectal cancer Metastasis HT-29-luc -
Lung Metastasis A549-luc -

Creative Animodel is dedicated to develop up-to-date solid tumor types to replenish our model bank which ensuring a wide variety of testing alternatives for your agents. The application of luciferase-labelled tumor cells in alliance with orthotopic or metastatic xenografts established by Creative Animodel allows non-invasive vital visualization of tumor development, progression, distribution as well as metastasis.

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-372-1052    Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-207-048-3343

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