Xenograft Models of Hematological Malignances
Expertised in construction of xenografts of hematological malignances, Creative Animodel supports techniques of intravenous injection based tumor xenografts such as leukemia and specific oncogene-initiated bone marrow transplantation model (BMT) establishment. Creative Animodel also supply patient-derived tumor xenografts (PDTX) cohorts and humanized-xenograft model as well as relative projects conduction.
Diverse hematological tumor xenograft models that being research hotspots provided by Creative Animodel encompass the following categories, but is not limited to:
Acute Lymphoblastic Leukemia (ALL)
Aculte lymphoblastic leukemia (ALL)，characterized by the overproduction and accumulation of cancerous, immature white blood cells，is an acute subtype of leukemia.
provides professional technical support to assist you in building elegant ALL models. Our PDX xenograft model services of ALL allow fundamental researchers to imitate tumor cellular context in ALL patients, which is critical in preclinical trials of a drug candidate.
Chronic Lymphoid Leukemia (CLL)
B-cell chronic lymphocytic leukemia, also known as chronic lymphoid leukemia, is the most common type of leukemia in adults (more than 75% patients newly diagnosed with CLL are over age of 50 exclusively affecting B cell lymphocytes originated in the bone marrow. Creative Animodel provides customers with novel humanized animal models, which overcome the barriers of inefficient and/or short-term engraftment of CLL by the commonly used xenotransplantation model.
Acute Myeloid Leukemia (AML)
Acute myeloid leukemia is characterized by the rapid growth of abnormal white blood cells accumulating in the bone marrow with increasing occurance along with the growth of age. Relevant preclinical mouse models are crucial to screen new therapeutic agents for AML. Creative Animodel assists you in building the most efficient xenograft model including both the well-characterized cell line-based and PDTX models and other vital prerequisites for testing new therapeutic agents in preclinical studies.
Chronic Myeloid Leukemia (CML)
Chronic myeloid leukemia, a kind of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome, is a clonal bone marrow stem cell disorder manifesting a proliferation of mature granulocytes and their precursors and accounting for 14% of leukemia totally. Creative Animodel provides customers PDTX model and humanized CML models by retrovirally expressing BCR-ABL1 in the cord blood CD34+ cells before transplantation to the NSG mice, which can successfully access to CML upon secondary transplantation.
Multiple Myeloma (MM)
Multiple myeloma, in which collections of abnormal plasma cells accumulating in the bone marrow so as to interfere the production of normal blood cells, is the second most common hematological malignancy in the U.S and is considered to be incurable but treatable. MM xenograft models in Creative Animodel are perfect choices for performing researches related to MM progression and therapeutic effect evaluation in vivo. Creative Animodel provides customers with both GFP transfected MM cell lines (such as OPM-2 and RPMI-8226) based model and PDTX models, which allows the tracking with tumor antigen like AKAP-4.
Hodgkin`s Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL)
Hodgkin's lymphoma, originated from lymphocytes is a kind of disease which occurrence both in young adulthood (age 15–35) and in those over 55 years old. Non-Hodgkin lymphomas (NHLs), are diverse group of lymphoma except Hodgkin's lymphoma with a five-year survival rates of 69% in the U.S, which varying significantly from slow growing to very aggressive types. Creative Animodel can offer customers xenograft models based on either HL cell lines or Burkitt lymphoma and defuse large B-cell lymphoma enclosed NHL cell lines so as to sustain your preclinical researches focused on antibody therapy or other mechanical exploration.