Metabolic syndromes (MTS) refer to a collection of abnormal conditions leading to metabolic complications. They include obesity, hypertension, hyperglycemia, hypertriglyceridemia and impaired HDL. MTS has drawn many researchers’ attentions as potential risk factors of diabetes, coronary heart disease, fatty liver and cancers. Creative Animodel provides a very good platform for studies of MTS related disease, we have a large number of documented NHP resources and professional services including conducting MTS research projects and drug evaluation in our customized NHP models.
Why NHP for Metabolic Disorders
Small animals like rodent are most commonly used model for studying MTS, however, other mammals including NHP also have superior advantage in these areas. Major NHP fat deposit mechanism is adipocytes proliferation, which is very similar to human, unlike adipose tissue enlargement in mouse. Moreover, mice model is reported to have different biological characters from NHP and human. Mice mainly carry “good cholesterol”, high density lipoprotein (HDL), is distinct from NHP and human lipid profile, which consist of both HDL and LDL. In obese condition, adipsin, a kind of adipokine, is relatively low in mice and high in human, and elevated resistin can reduce glucose tolerance in mice but has no effect in human.
Type I&II Diabetes Mellitus (T1DM and T2DM)
Creative Animodel is able to provide both spontaneous and induced NHP model for type I and II diabetes researches. Our spontaneous T2DM model model is mostly developed from rhesus, cynomolgus monkey and several other species with fasting blood glucose range from 5.6-7mmol/L. Customize T2DM model can be created by standard protocol or as request. Creative Animodel generally produces T2DM model by using streptozotocin (STZ). STZ is a natural toxin can kill insulin-producing beta cell of pancreas. Based on different application dosage, STZ treated primate can develop either T1DM or T2DM symptoms. Namely, single injection of large quantity of STZ will lead to demise of almost all insulin-producing cells (T1DM), and multi-treatments of small amount of STZ in primate will lead to incidence of T2DM. To minimize hepatic and renal toxicity of STZ, Creative Animodel also applies pancreatectomy method to develop T1DM model, partial removal of pancreas combined with low dosage of STZ treatment can increase successful rate of T1MD model meanwhile reduce by-effect to liver and renal tissue.
Obesity is considered as major risk factor of many metabolic diseases, Creative Animodel will work with our clients by providing best spontaneous and diet-induced NHP obesity model. Creative Animodel has established large pedigreed colonies of primates and we selectively maintain a number of primates with spontaneous obesity. These spontaneous NHP models mainly develop from rhesus, cynomolgus monkey and several other species and they usually accompany with potential obesity-associated diseases such as diabetes, hypertension and cardiovascular diseases. The diet induced obesity is developed by feeding high fat/high calorie diets and housed with less exercise. These models can be extensively used for studies of obesity-related complications and metabolic responses to high fat diets. Our personnel in Creative Animodel have extensive experience in designing, conduct and interpreting projects of metabolic disorders. Our capabilities include but not limit to: customizing dietary formula, biopsy assessments (liver, pancreas, muscle, adipose tissue etc.) and non-invasive scanning (PET and MRS).
High fat diet for obese primate model creation