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Phototoxicity


Phototoxicity is the toxic response of a substance when applied to the body. It is either elicited or increased (apparent at lower dose levels) after subsequent exposure to light, or that is induced by skin irradiation after systemic administration of a substance. Both topically applied and systemically administered therapeutic drugs have the potential to induce phototoxicity. Substances that are phototoxic can cause damage to skin cells and tissues, such as visible redness, rash, and swelling. More importantly, phototoxicity may cause changes in skin color and lead to skin cancer. Cells in the eye that are responsible for vision may also be damaged by phototoxicity and leads to cataracts and other problems.

Creative Animodel provides a comprehensive phototoxicity testing service to evaluate the safety of pharmaceutical, chemical, cosmetic and consumer products. Both in vitro and in vivo models are available for pre-clinical phototoxicity assessment. We have an experienced team that design and conduct phototoxicity studies for you and ensure the tastings meet both standard and specialized requirements. The pre-clinical phototoxicity assessment of compounds can support the clinical trials and marketing authorizations for pharmaceuticals and chemicals.

In vitro test system

3T3 neutral red phototoxicity test - An well established in vitro toxicological assessment test. The principle is to compare the cytotoxic and photo(cyto)toxicity effect of a chemical in a permanent murine fibroblast cell lines (Balb/c 3T3) in the presence and in the absence of a non-cytotoxic dose of UVA/visible light. It is a highly sensitive assay, if a compound is negative in this assay it would have a very low liability of being phototoxic in humans.

In vivo test

Photo-irritation & sensitization assays-In vivo test can be conducted in a variety of species, including mice, rat or guinea pigs. The animal is treated with the chemical in combination with UV, followed by an examination of skin reactions (erythema, pain and swelling) and a histopathological investigation of the skin. Selection of irradiation conditions is critical for both in vitro and in vivo assays. UVA doses ranging from 5 to 20 J/cm2 are successfully used in current in vitro and in vivo phototoxicity assays.

Creative Animodel has extensive experience and expertise in phototoxicity studies as well as animal experiments. Customized studies will be design based on the physical and chemical property of your interested compounds. All the phototoxicity services would follow regulatory guidelines to ensure test reliability, high quality, timeliness, and cost-effectiveness.

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USA
45-1 Ramsey Road, Shirley,
NY 11967, USA
Tel: + 1-631-372-1052
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Tel: + 44-207-048-3343

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Website: www.creative-animodel.com



45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-372-1052    Fax: 1-631-614-7828
Email: 

Europe
Tel: 44-207-048-3343

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