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Animal Models of Noise-Induced Hearing Loss

Creative Animodel provides the most useful animal models for investigating Noise-Induced Hear Loss (NIHL). Our experienced experts will access the objectives and parameters of your particular research project, and come up a comprehensive and systematic plan to use the most matching animal model to reach your specific research goal.

Which animal model is the most useful for investigating NIHL and to what extent is it possible to extrapolate from animal models to humans? The answer to the question is complex and probably depends on the specific issue or problem being investigated. With our expertise and experience, we are able to help you to select the most matching animal model, and design the most effective set of experiments. We can conduct studies for sensorineural hearing using cat, chinchilla, gerbil, guinea pig, mouse, and rat.

Creative Animodel has built a comprehensive technical platform for studying NIHL, which includes the following categories, but is not limited to:

• Behavioral Assessment of Noise-Induced Hearing Loss
• Exposure Level and Duration
• Recovery
• Frequency Selectivity
• Temporal Resolution
• Histopathologies Associated with Noise-Induced Hearing Loss
• Scanning Electron Microscopy and Stereocilia Damage
• Surface Preparation Technique and Cochleogram
• Physiological Measures of Noise-Induced Hearing Loss
• Pharmacological Strategies for Preventing Noise-Induced Hearing Loss

In industrialized countries where recreational and work place noise are increasing, noise-induced hearing loss (NIHL) has become the leading cause of hearing loss among those under 50 years of age. The early studies of NIHL in humans between 1940 and late 1960 helped to establish a basic understanding of the magnitude of the hearing loss resulting from noise exposures of a given intensity, duration, and spectral content; however, because of ethical constraints and the difficulty of carrying out long-term noise exposure with humans, most of the early human studies focused on sound exposures that resulted in temporary threshold shifts (TTS).

Noise-Induced Hearing Loss

Creative Animodel fully understands the growing concern that TTS-inducing sound exposures might cause permanent damage to the sensory cells, supporting cells, and spiral ganglion neurons in the inner ear, our major technical approach and problem-solving strategies for NIHL focus on using animal models, in particular, aiming at understanding the basic neuroanatomical, neurophysiological, biochemical mechanisms underlying NIHL, as well the evaluation of your new drugs, devices and therapeutics to prevent and treat NIHL.

Since the hair cells in the mammalian inner ear do not spontaneously regenerate, preventing NIHL hearing loss from occurring has become a major research focus. Since high-level noise exposures appear to generate toxic reactive oxygen species such as the superoxide radical, hydrogen peroxide, and the hydroxyl radical, a promising approach to preventing NIHL is to enhance the antioxidant capacity of the inner ear using endogenous or exogenous therapeutic agents. Creative Animodel will be with you on each step of for obtaining meaningful and suggesting data from animal model studies for NIHL. Therefore, we will be of your strongest assistanceyou're your translational research, which aims at preventing and curing NIHL in humans who are routinely exposed to high-level noise.

* For research use only. Not intended for any clinical use.

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