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Indomethacin-Induced Inflammation in Small Intestine

Creative Animodel is a leading company offering the best animal model creation service. We have talented scientists who have years of experience in inflammatory bowel disease. They would work closely with you to provide help in model selection, model creation and data collection.

Indomethacin (INN) is a nonsteroidal drug with anti-inflammatory anti-pyretic and analgesic properties. It is commonly used to decrease the fever, pain and other effects caused by inflammation. Interestingly, small intestinal inflammation as Crohn’s disease could be induced by two 24 hour apart subcutaneous injections of indomethacin in rat 1. Although the reason that caused the inflammation is not clear yet, it is believed that the injection of indomethacin could significantly increase the mucosal permeability of small intestine and further cause damage and inflammation condition to the small intestine. These symptoms make it an appropriate model for Crohn’s disease research and could be used for new drug or therapy investigation.

Indomethacin-Induced inflammation in Small Intestine

Figure 1 Effect of INN induced inflammation. (a, b-Control; c, d-Indomethacin, 5mg/kg) 2

Creative Animodel is a creative and reliable partner in your research. We understand the acquisition of animal model is an important step in your project. Our experts would assist you to choose the most appropriate animal model for your research and offer the strategy and experimental design that best fit your needs.

Creative Animodel also provides various preclinical service for IBD, which includes, but not limited to:

• Assessment of Inflammation score
• PK/PD blood collection
• Body weight measurement
• Gut immunohistochemically images
• MPO (Myeloperoxidase) activity assessment
• Assessment of pro-inflammatory cytokines including IL-1β, IL-6, IFN-γ, TNF-α
• Endoscopy imaging
• Analyses of inflammation related miRNA (miRNA qPCR, miRNA microArray)

Indomethacin-Induced inflammation in Small Intestine

Figure 2 Selected preclinical service 3

Creative Animodel is dedicated to ensuring that all our service and products are at the highest level of quality. We offer different inflammatory bowel disease models for different type of researches. Our preclinical service provides results including assessment of weight loss, evaluation of inflammation, MPO activity check, level of pro-inflammatory cytokines and tissue immunohistochemistry. These results helps to estimate the severity of inflammation and assists to evaluate the effects of your potential anti-inflammation drugs or treatments.

For the past 10 years, Creative Animodel has delivered models and service that meet the needs of different researchers. We are a reliable partner that can work with you to accelerate the speed to achieve your research goals.

1. Yasuoka T, Sasaki M, Fukunaga T, Tsujikawa T, Fujiyama Y, Kushima R, Goodlad RA. The effects of lectins on indomethacin-induced small intestinal ulceration. Int J Exp Pathol 2003;84:231-7.
2. Silva M, Rao V, Souza C, Neve J, Menezes D, Santos F, Andrade G. Evaluation of thalidomide against indomethacin-induced small intestinal damage and systemic toxicity in rats. Biomedical Research 2012; 23(1): 125-133.
3. Kim JJ, Shajib MS, Manocha MM, Khan WI. Investigating intestinal inflammation in DSS-induced model of IBD. J Vis Exp 2012.
* For research use only. Not intended for any clinical use.

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