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Models of Hematopoietic Diseases

Animal models are important biology tools to address hematopoietic disorders, as well as to give the view of these as a stochastic competition between different cell lineages, under the mutation and selection across the hematopoietic tree. Creative Animodel provides disease models for better understanding a series of new challenges in hematopoiesis, including blood cell production, the periodicity of cyclical neutropenia, stem cell production in response to cytokine administration, and the emergence of imatinib resistance in chronic myeloid leukemia. The approaches we used to induce animal models also provide a novel perspective for looking at the progression and cure of hematopoietic diseases.

Models of Hematopoietic Diseases

Hematologic Disorders:
● Bleeding disorders
・ Platelet function
・coagulation factor
● Platelet deficiency
・ Thrombocytopenia/Thrombocytopathia
● Red blood cell disorders
● White blood cell disorders

There are several models available in Creative Animodel, the spontaneous, chemically induced and viral induced models which are traditional models been used for years, now being to give way to xenograft, genetically engineered models (GEM) and even mosaic approaches. These models are developed to investigate the factors involved in malignant transformation, invasion and metastasis, as well as to examine response to therapy.

Models of Hematopoietic Diseases

Chemically Induced Models
● Adenine induced rat model of renal anemia
● Maryland induced myelosuppression aplastic anemia model
● Benzene induced myelosuppression aplastic anemia model
● Cyclophosphamide induced lenkocytopenia
● SesquiterpeneT-2 induced alimentary toxic aleucia

Viral Induced Models
● MULV (murine leukemia virus) induced leukemia
● Vertically transmitted disease (mother’s milk)
● Retroviral insertional mutagenesis

Xenograft Models
● Nude (nu/nu) mice
● Rag1 or Rag2 KO
● Scid/Scid-spontaneous recessive mutant involving the Pkrdc gene
● Non-obese diabetic (NOD)/Scid
● NOG/Scid-NOD/IL2rg deficient/Scid

Genetically Engineered Models (GEMs)
● Transgenic models: injection in fertilized eggs

Genetically Engineered Models (GEMs)

● knock-in and knock-out models (KI and KO): injection in embryonic stem cells, and replaced in blastocysts

Genetically Engineered Models (GEMs)

Among these models, mouse and rat stains are most preferred models for exploring the mechanisms underlying the disease and its treatment, we also perform different species such as pig and rabbit to model abnormal human hematopoiesis according to your needs. These animals have been employed the integrated team in Creative Animodel for experimental disease researches of human hematopoiesis. To learn more models of hematopoietic diseases, please refer to the content we have in the following:
Blood Cancer
Leukemia (AML, ALL)
Myelodysplastic Syndrome (MDS)
Myeloproliferative Neoplasms (MPN)
● Leukopenia
・Cyclophosphamide Induced Lenkocytopenia
・Alimentary Toxic Aleucia
・Cyclic Neutropenia
● Red Cell Diseases
Sickle Cell Anaemia
・Joint Red Cell Unit
・Iron Deficiency Anemia
・Aplastic Anemia
● Haemostasis and Thrombosis
● Diagnostic Haematology

* For research use only. Not intended for any clinical use.

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