Patient-Derived Xenograft Models


Creative Animodel has partnered with more than 10 research institutes and hospitals to get access to versatile patient-derived tumor xenograft (PDX) models with well-defined molecular characteristics for your individual study. Patient samples adopted to establish PDX models in Creative Animodel are from either treat-naïve or resistant patients, which enabling genetic and phenotypic heterogeneity retaining after the engraftment into highly immune-deficient NSG mice.

Creative Animodel has built a relatively complete PDX model bank for immediate execution of in vivo tests including the following cancer species but not limited to:

Category Diagnosis Characteristics
Acute Myeloid Leukemia - Query
Acute Lymphoblastic Leukemia - Query
Bladder Cancer Urothelial Carcinoma Invasive Query
Urothelial Carcinoma Query
Brain Cancer - Query
Breast Cancer Carcinoma Query
Invasive Ductal Carcinoma Query
Metaplastic Spindle Cell Carcinoma Query
Mixed Ductal Carcinoma Query
Ductal Carcinoma Query
Metastatic Adenocarcinoma Query
Ductal Carcinoma In Situ Query
Cervical cancer   Query
Colorectal Cancer - Query
Esophageal Cancer - Query
Gastric Cancer - Query
Head & Neck Cancer - Query
Kidney Cancer - Query
Liver Cancer Cholangiolar Query
Hepatocellular Query
Lung Cancer NSCLC: Adenocarcinoma Query
NSCLC: metastatic adenocarcinoma Query
NHL DLBCL Query
Melanoma - Query
Ovarian Cancer Ovarian serous adenocarcinoma Query
Papillary serous adenocarcinoma Query
Ovary serous adenocarcinoma Query
Adenocarcinoma Query
Pancreatic Cancer Pancreatic Ductal Adenocarcinoma Query
Ampulla of Vater Adenocarcinoma Query
Metastatic Adenocarcinoma Query
Pleuramesothelioma - Query
Prostate Cancer - Query
Sarcoma Osteo- Query
Soft tissue Query

PDX models can offer the closest available alternative to clinical testing for researchers who need to evaluate cancer drug efficacy, for the reason that this kind of models retain primary tumor properties and metastasis behavior. Creative Animodel   created models using dissociated tumor cells from biopsies that can better reflect the heterogeneity and sophistication of tumors, which will benefit the preclinical drug candidates screening procedure. Our PDX models can satisfy customers in the researches on molecular characteristics as well as the biological functions of the primary tumors cells, which include migration, metastasis, drug resistance, and tumor relapse. The advanced PDX models, in alliance with our traditionally existing cultured cell line-derived xenograft models, offer customers a more broad range of testing options for potential cancer therapies.

Ex-vivo Tumor Patient Study Platform

Ex-vivo Tumor Patient Study Platform

In addition, patient-derived tumor ex vivo study platform has been established by Creative Animodel to extend tissues or primary cells-related researches. This platform directly delivers the primary cancer cells or tissues to ex vivo compound activity profiling which enabling an extensive survey of drug response in diverse disease background. Based on our widespread cooperation with research and clinical institutes, Creative Animodel also renders customized service for PDX models other than the referred tumors. Please feel free to contact us for more information or to get access to your individual projects involving with preclinical drug evaluation or biomarker identification.

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