To support new therapeutics discovery and research for hematopoietic disease, using animals to study hematology and disease intervention, as well as for a success gaining of IND approval, Creative Animodel provides custom preclinical animal studies from model development, lead drug candidate efficacy studies, to toxicology testing that made specifically for human hematopoiesis. We will advance your studies via different approaches to reproduce normal hematopoiesis across mammals and to understand the mechanism of various disorders both in humans and in animal models. We also offer a board suite of services including animal health monitoring, in vitro blood assays and data analysis to address your needs.
Available Species and featured technology offered by Creative Animodel:
Zebrafish
• Transparent embryos for developmental biology
• ENU mutagenesis for genetics
• CRISPR technology
• Statistics for blood cancer
Xenopus
• Animal cap experiments for tissue induction
• FATE map of 32-cell embryo
• Dominant-negative constructs
Mouse
• Excellent genetics with many banked mutants
• Physiology to test organ function
• Tumor xenografts
Non-Human Primate
• Organ physiology similar to humans
Human cells
• Transplantation of tumors and stem cells into mice
We offer the following application systems for hematopoietic disease:
Models that we offer, but are not limited to the following:
For modeling the immune response and rational immune approaches in human hematopoiesis, we also provide transgenic and immunodeficiency mice models which have performed useful assay system for the development of novel vaccines and therapeutic agents. Our immunodeficiency mouse models include:
Single gene mutation mice
Multiple gene mutation mice with additional defects in innate and adaptive immunity
Humanized immunodeficiency mice
In addition to board-certified animals with hematopoiesis data, Creative Animodel also sets up a platform for blood testing and preclinical services to better understand advanced therapeutic development.
Our Service Platform:
Advantages of Creative Animodel