Increasing number of diabetes and obesity population in developed countries suggests elevated risk of cardiovascular diseases (CVD), which has ranked first leading cause of death by WHO. NHP cardiac disease models provided by Creative Animodel offer very good platforms to discover novel and efficient therapeutic approaches for CVD.
Cardiac arrhythmia is characterized by irregular heart beating rate and major arrhythmias includes extra beat, supraventricular tachycardias, ventricular arrhythmias, and bradyarrhythmias, severe medical conditions such as stroke and cardiac arrest can be developed after untreated arrhythmias.
Based on different research purposes, Creative Animodel provide open and close-chested NHP model for arrhythmias studies.
Atherosclerosis is a condition of fibrofatty plaque growth on intimal artery wall. As result of accumulation of white blood cells and death cell remained cholesterol and triglycerides, plaque on cell wall can reduce vessel elasticity and eventually rupture. Plaque rupture induce formation of thrombus, which can impair blood flow, cause tissue death and cardiac complications. In Creative Animodel, we supply diet-induced, diabetes-accelerated and plaque rupture models for atherosclerosis experiments.
Myocardial Ischemia/Infraction Reperfusion Model
Myocardial ischemia occurred by blood clot, coronary artery disease or spasm, which result in attenuate blood flow and restricted oxygen supplied to cordis tissue. Ischemia can diminish heart muscle pumping efficiency and damage myocardial cells, prolonged ischemic condition will lead to heart cell necrosis and eventually cause myocardial infraction (commonly known as heart attack). By using clot-busting drug or arteries opening equipment, blood flow can be restored after ischemia and this process is termed reperfusion. Previous researches revealed reperfusion can further injure myocardial tissue by inflammation and producing reactive oxygen species. Creative Animodel provides customers with both acute or chronic ischemia model, and myocardial infraction reperfusion model of primates.