As growth of aged population, age-related degeneration become leading cause of retina and optic nerve damage, which draw lots of attention to studies of visual impairment and ocular diseases. Creative Animodel group fully understands ophthalmic disease research is a challenging and time-consuming process, we would like to help accelerating this courses by providing our top-quality primate ocular disease models and related services.
Why NHP for ophthalmological disease model?
Primates are only animal having closest ocular structure to human, and primate has advantages of bigger ocular size than other animal model and has macula in retina, which is major researching site of DR and other ophthalmological diseases.
Diabetic Retinopathy (DR)
As diabetic complication, DR is characterized with retinal microvascular damage, presence of microaneurysms and dot. Creative Animodel develops DR primate model by chemical induction with streptozotocin (STZ) or surgical pancreatectomy. Diabetic primate model reveals characters such as exudate in macula, retinal hemorrhages or macular edema in aged monkey.
Creative Animodel has highly specialized equipment and skilled personnel to develop primate glaucoma model. We use argon laser treatment to induce formation of fibrin meshes and block trabecula space, to increase intraocular pressure (normally higher than 21mmHg). To avoid concern of inflammatory damage caused by repeating laser treatment, Creative Animodel also provide microbead injection technique to increase ocular hypertension.
Choroidal Neovascularization (NV)
Creative Animodel uses argon laser to break Bruch’s membrane and induce choroidal NV. Newly-formed vessel analysis such as total area of blood vessel leakage, percentage of laser lesion
and extension of new vessel growth can be conduct by fluorescein angiography.
Available ophthalmological disease models and estimated timeline.
|Diabetic Retinopathy||STZ or alloxan induction||Mouse, Rat, and Rabbit||6 to 24 weeks|
|Pancreas removal||Cat||Need contact|
|STZ or alloxan induction; or obese diet||Dog||Need contact|
|Pancreas removal or STZ induction||Primate||Need contact|
|Age-related Cataract||STZ or alloxan induction||Mouse, Rat, Rabbit, guinea pig||6 to 24 weeks|
|UV-indcued cataract||Mouse, Rat, Rabbit and guinea pig||1 to 6 weeks|
|PVR||Rabbit conjunctival fibroblasts||Rabbit||4 to 6 weeks|
|Injection of dispase||Mouse and pig||4 to 8 weeks|
|Glaucoma/IOP||Laser photocoagulation||Mouse, rat and primate||2 to 4 weeks|
|Microbead injection||Mouse, rat, rabbit, pig and primate||4 to 12 weeks|
|Uveitis||LPS induction||Mouse and rat||24 to 72h|
|EAU induced by IRBP protein||Mouse and rat||2 to 8 weeks|
|Dry eyes||Botulinum Toxin B||Mouse and rat||2 to 8 weeks|
|Into lacrimal gland|
|Long term- injuring facial nerve||Rabbit||2 to 12 weeks|
|Ocular tumor||Uveal melanoma cell injection to anterior or posterior chamber||Mouse, rat and rabbit||Need contact|
|Corneal NV||Alkali treatment||Mouse and rat||1 to 4 weeks|
|Choroidal NV||Argon laser treatment||Mouse, rat and primate||4 to 16 weeks|
|Retinal N||STZ induction||Mouse, rat and rabbit||2 to 16 weeks|