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Ocular Disease Model

As growth of aged population, age-related degeneration become leading cause of retina and optic nerve damage, which draw lots of attention to studies of visual impairment and ocular diseases. Creative Animodel group fully understands ophthalmic disease research is a challenging and time-consuming process, we would like to help accelerating this courses by providing our top-quality primate ocular disease models and related services.

Why NHP for ophthalmological disease model?
Primates are only animal having closest ocular structure to human, and primate has advantages of bigger ocular size than other animal model and has macula in retina, which is major researching site of DR and other ophthalmological diseases.

Diabetic Retinopathy (DR)
As diabetic complication, DR is characterized with retinal microvascular damage, presence of microaneurysms and dot. Creative Animodel develops DR primate model by chemical induction with streptozotocin (STZ) or surgical pancreatectomy. Diabetic primate model reveals characters such as exudate in macula, retinal hemorrhages or macular edema in aged monkey.

Ocular Disease Model

Creative Animodel has highly specialized equipment and skilled personnel to develop primate glaucoma model. We use argon laser treatment to induce formation of fibrin meshes and block trabecula space, to increase intraocular pressure (normally higher than 21mmHg). To avoid concern of inflammatory damage caused by repeating laser treatment, Creative Animodel also provide microbead injection technique to increase ocular hypertension.

Choroidal Neovascularization (NV)
Creative Animodel uses argon laser to break Bruch’s membrane and induce choroidal NV. Newly-formed vessel analysis such as total area of blood vessel leakage, percentage of laser lesion
and extension of new vessel growth can be conduct by fluorescein angiography.

Choroidal Neovascularization (NV)

Available ophthalmological disease models and estimated timeline.

Disease model Procedure Animal Time
Diabetic Retinopathy STZ or alloxan induction Mouse, Rat, and Rabbit 6 to 24 weeks
Pancreas removal Cat Need contact
STZ or alloxan induction; or obese diet Dog Need contact
Pancreas removal or STZ induction Primate Need contact
Age-related Cataract STZ or alloxan induction Mouse, Rat, Rabbit, guinea pig 6 to 24 weeks
UV-indcued cataract Mouse, Rat, Rabbit and guinea pig 1 to 6 weeks
PVR Rabbit conjunctival fibroblasts Rabbit 4 to 6 weeks
intravitreous injection
Injection of dispase Mouse and pig 4 to 8 weeks
Glaucoma/IOP Laser photocoagulation Mouse, rat and primate 2 to 4 weeks
Microbead injection Mouse, rat, rabbit, pig and primate 4 to 12 weeks
Uveitis LPS induction Mouse and rat 24 to 72h
EAU induced by IRBP protein Mouse and rat 2 to 8 weeks
Dry eyes Botulinum Toxin B Mouse and rat 2 to  8 weeks
Into lacrimal gland
Long term- injuring facial nerve Rabbit 2 to  12 weeks
Ocular tumor Uveal melanoma cell  injection to  anterior or posterior chamber Mouse, rat and rabbit Need contact
Corneal NV Alkali treatment Mouse and rat 1 to 4 weeks
Choroidal NV Argon laser treatment Mouse, rat and primate 4 to 16 weeks
Retinal N STZ induction Mouse, rat and rabbit 2 to 16 weeks
* For research use only. Not intended for any clinical use.

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