Creative Animodel offers physicochemical property determination services for small molecules, oligonucleotides, peptides, and industrial and consumer chemicals.
Solubility--- The turbidimetric solubility of your test agent in various buffers, cell culture media, or biological fluids will be determined. Thermodynamic solubility will be determined by HPLC or LC-MS/MS analysis.
Chemical Stability--- Test agent is incubated in artificial gastric or intestinal fluids to simulate the fed or fasted states. Moreover, the stability of a test agent in various buffers and across a pH range is measured.
PAMPA Permeability--- Measures the permeability of a test agent across an artificial membrane.
Absorption can occur either through passive transcellular diffusion or through active carrier transport mechanisms. Distribution processes are also very important in influencing tissue distribution and can be major mechanisms of excretion.
Creative Animodel offers an extensive portfolio of assay-based products and services including:• Pampa (Gi/Bbb)
There is a significant advantage to obtain metabolism data as early as possible in the drug discovery process. Understanding how a drug compounds' enzymatic metabolic pathways and metabolic rates influence its clearance, metabolite concentration, and potential drug-drug interactions is a critical component to developing safe and effective drugs.
At Creative Animodel, a variety of assay matrices, including pooled liver microsomes, pooled liver S9 fraction, hepatocytes, human recombinant cytochrome P450s, UGTs, blood and plasma, are used for the metabolic assessment of hits, leads, and new pharmaceutical compounds.
Drug-drug interaction is a modification of the effect of a drug when administered with another drug. This can alter the way one or both of the drugs act in the body, or cause unexpected side effects. Early stage screening of compounds for potential drug-drug interactions using in vitro techniques becomes necessary in order to decrease late stage compound attrition. Creative Animodel has developed a set of in vitro tests which address: