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Safety Pharmacology

Safety pharmacology is the study of the potential undesirable pharmacodynamic effects of a substance in relation to dosage within the substance's therapeutic range and above. It provides valuable insight into a drug's adverse effects, preview what may be observed clinically and provide essential information about likely side effects on the major physiological systems of the body. Creative Animodel offers a complete range of GLP-compliant ICH S7A core battery tests to determine the potential undesirable pharmacodynamic effects of a compound.

Our core battery services incorporate tests to detect effects on:
   • Central Nervous System
   • Cardiovascular System
   • Respiratory System

In contrast to the core battery, some organ systems can be transiently disrupted without irreversible harm and are of less concern:

   •Gastrointestinal System
      Gastrointestinal Transit Time
      Gastric Damage
      Gastric Secretion (Pyloric Ligation)
   •Renal System
   •Additional Supplementary Tests
      Abuse Liability Testing
      Analgesic Assessment
      Bleeding Time
      Body Temperature
      Motor-In Coordination (Rotarod)
      Proconvulsant Activity
      Sleeping Time

Creative Animodel consults with you to design animal study protocols balancing timing, cost and risk factors, ensuring appropriate data to support pre-clinical studies as well as the first human administration of new candidate drugs. Our regulatory expertise can also help with preparation of your submission.

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* For research use only. Not intended for any clinical use.

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