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Ocular Toxicology

Ocular toxicity usually occurs due to intended or unintended exposure of ocular tissues to xenobiotics. It is induced following local exposure of the eye to an agent or after exposure via oral or other administration routes. It is important to assess the ocular toxicity of a drug before clinical application. In order to define the risks, the pharmaceuticals, pesticides and other toxic substances pose to the eye, Ocular toxicity testing in animal species are extensively used. The design of these studies is dependent upon the regulatory authority, nature of the product and other factors.

Creative Animodel performs safety and efficacy assessments for all ocular indications. Ocular effects of compounds administered by other routes, such as oral, can also be characterized. Ocular toxicity studies can be conducted under GLP or non-GLP conditions, either as stand-alone studies or as part of general and specialty toxicology programs. A number of animal species can be used for ocular toxicity studies, including rodents, rabbits, small animals, dogs, and mini pigs.

• Tested Compound Classes
-Small molecule
-Cell therapy
-Gene therapy

• Administration routes include but not limited to:
-Intravitreal injection
-Anterior chamber injection
-Subconjunctival injection
-Subretinal injection.

• Techniques
-Specular microscopy for noninvasive, in vivo evaluation of the corneal endothelium
-Spectral domain optical coherence tomography (SD-OCT, anterior and posterior)
-Tonometry (IOP) evaluations
-Pachymetry (corneal thickness)
-Digital fundus photography/video
-Confocal scanning laser ophthalmoscope (multiple image modes - infrared and tomography for 3D images)
-Fundus autofluorescence
-Fluorescein angiography (FA) and Indocyanine green angiography (ICG)
-Quantitative autoradiography
-Ocular and systemic tissue distribution
-Enhanced microscopic evaluation
-Ocular surgery/implant

• Features:
-Over 20 years of experience
-Specialized techniques and qualified management team
-Comprehensive supportive services
-Experienced ophthalmologists and toxicologists

The eye reflects changes both in neurological and vascular functions. Creative Animodel has performed safety assessments of test articles administered via numerous ocular routes for decades and has extensive expertise in ocular toxicity study after systemic or local administration. All ocular toxicity examinations are performed by qualified ophthalmologists, working in close collaboration with experienced toxicologist, to ensure a well-integrated interpretation of results.

* For research use only. Not intended for any clinical use.

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