45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052

Car-T Pharmacological Study

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Car-T Pharmacological Study

Creative Animodel provides customized preclinical testing services for your Engineered Chimeric Antigen Receptor T (CAR-T) cells. In cooperation with our CAR-T cells production division, Creative Biolabs, we are able to provide you with one-stop full service of both CAR-T production and preclinical testing. We also offer services for customized CAR-T cell toxicity management assessments.

CAR-T cell is the leading immune-therapy in oncology. Clinical trials have produced encouraging results in CAR-T involved cancer treatments. Despite the positive results from the clinics, CAR-T therapy associated safety issues still pose risks in its clinical applications. Preclinical assessment of CAR-T efficacy and safety are necessary for its dosage determination and risk managements.

We conduct CAR-T cell preclinical studies in human tumor sample derived xenograft mouse/rat models. Immunodeficient mice/rats that lack functional B cells, T cells, or NK cells, and with reduced innate immunity are the optimal animal models for engraftment of human tumor cells. In addition, these immunodeficient small animals also support engraftments of the modified human immune system, including CAR-T cells, for better clinical modeling.

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CAR-T preclinical studies in human tumor xenograft mouse/rat model

Services for CAR-T Pharmacokinetic studies
> CAR-T serum persistence and engraftment
> CAR-T biodistribution and tissue infiltration
Services for CAR-T efficacy studies
> Tumor cell measurements: size measurements for solid tumor, body weight; tumor cell counts and
    flow cytometry analysis of peripheral blood and bone marrow for hematopoietic tumor
> End point animal necropsy for tissue weighing
> Tumor size monitoring by bioluminescent imaging
Services for CAR-T toxicity and safety evaluation
> Cytokine panel analysis (end point or time course)
> Blood cell and bone marrow content monitoring by flow cytometry
> Cytotoxicity analysis for determine effector: target ratio and cell necrotic risk assessments

Creative Animodel consistently keeps an eye on the up-to-date techniques around the world, so as to satisfy the customers’ urgency by timely renewing and replenishing our existing services. Our experienced scientists will help you to develop the study proposal that best suits your purpose and fast advance your drug through clinical trials. Please feel free to contact us for your individual research project.

Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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Telephone: Email: 1-631-372-1052 bd@creative-animodel.com Please fill out the form below:
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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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