45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-207-8356 1-631-871-5806

Car-T Pharmacological Study

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CAR-T Therapeutic Efficacy Study

Creative Animodel provides preclinical in vivo studies for your Engineered Chimeric Antigen Receptor T (CAR-T) cell efficacy in tumor xenograft animal models. Our services will provide valuable information for clinical outcomes predictions and toxicity evaluations.

Chimeric antigen receptor T (CAR-T) cells are engineered T lymphocytes that are able to recognize tumor specific antigens and induce programmed cell death. The specificity and potency of antigen recognition plays the key role during CAR-T treatments. In recent clinical trials, CD19 CAR-T cells have produced 70%-90% of successful targeting against CD19+ B lymphocyte leukemia in young adults and children. The impressive clinical results have inspired further development of CAR-T cell therapy against other types of cancers. Preclinical efficacy study of CAR-T cells in animal models provides valuable information for its application in later clinical trials.

In Vivo Studies for Your CAR-T Cell Efficacy

Hematopoietic cancer
Efficacy study of CAR-T cells targeting hematopoietic cancers focuses on the aspects of tumor cell counts, analysis of the cell content of peripheral blood cell and bone marrow, and survival analysis of CAR-T treated animals. We provide both end point and time course studies.

Figure 1. BD FACSAria flow cytometer for analysis of hematopoietic and bone marrow cell content

Analysis methods:
• FACS analysis of hematopoietic cell content
> Peripheral blood
> Bone marrow
• Kaplan-meier survival analysis

Solid tumor
Efficacy evolution of CAR-T cells against solid tumor focuses on monitoring of tumor size during the course of treatment and immunestochemistry analysis of xenograft tumor samples after the treatment.

Figure 2. Tumor cell monitoring by bioluminescent imaging

Analysis methods:
• Tumor size measurements
• Animal necropsy and immunohistochemistry (IHC) study
• Bioluminescence imaging of tumor size and metastasis
• Kaplan-meier survival analysis

Efficacy studies at Creative Animodel can be applied to engineered T lymphocytes (CAR-T), engineered NK cells (CAR-NK) and any other modified version of cell therapy against tumors. Our experienced scientific support team will assist you to choose the most suitable analysis combination for your CAR-T therapy efficacy evaluation. With our state-of-the-art technology, we will provide you with high-quality service to advance your drug through clinical trials.

Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-207-8356 1-631-871-5806 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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