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Angiogenesis

Creative Animodel offers a complete range of preclinical laboratory services for novel drug screening. Our services can support establishing animal models, DMPK analysis, safety evaluation and toxicity testing, and experimental subjects involve cell, tissue, and animal, covering in vivo and in vitro. As for cell services, we provide comprehensive tests, such as viability, proliferation, angiogenesis etc. to meet your needs for specific research requirements or drug safety studies.

An Overview of Angiogenesis

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Endothelial cells that line the vasculature are normally quiescent but can be induced to proliferate, migrate, and form new blood vessels when stimulated by angiogenic factors. This process is referred to as angiogenesis. Angiogenesis occurs in disease conditions such as tumor growth and diabetic retinopathy as well as in some normal processes such as wound healing and embryonic development. Over the past 40 years, more and more recognition was received that angiogenesis has therapeutic value. Angiogenesis shows good therapeutic capacity in ischemic heart disease, peripheral arterial disease, and wound healing. While in cancer, ophthalmic conditions, rheumatoid arthritis, and other diseases, decreasing or inhibiting angiogenesis will have good therapeutic effects. According to functional demands, angiogenesis performs different functions.

Angiogenesis Studies at Creative Animodel

Angiogenesis tests are an essential part of normal developmental processes and numerous pathologies, but one of the problems faced by angiogenesis researchers has been the difficulty of choosing a proper suitable method to detect the effects of regulators. At Creative Animodel, our experienced experts will choose the most suitable approach and help design the proper plan for your research.

Services we provided but not limited to:
• Chorioallantoic Membrane (CAM) Assay
• Tube Formation Assay
• Co-Culture Angiogenesis Assay
• Matrigel Plug Assay
• Platelet Activation Assay
In Vivo Angiogenesis Assays

Creative Animodel has the capacity of innovative study designs, optimal facilities, and strong regulatory intelligence, all of which guarantee our clients can get high-quality results with lower cost and less time. Our ability of angiogenesis research will allow you to target address the main objectives with lower investment. Please contact us for further support in the development of your drug.

References:
1. Auerbach, R.; et al. Angiogenesis assays: a critical overview. Clinical chemistry. 2003,49(1), 32-40.
2. Carmeliet, P. Angiogenesis in life, disease and medicine. Nature. 2005,438(7070), 932-936.
3. Aranda, E.; et al. A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA. hy926 endothelial cell line. Biological research.2009, 42(3), 377-389.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-207-8356 1-631-871-5806 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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