Cancer Cell Line Panel Screening
Creative Animodel is a professional contract research organization (CRO) which provides comprehensive preclinical drug screening and testing services for global pharmaceutical companies and research institutes. Our company has the most advanced technology platforms and experienced technical staff to ensure the high-quality services. Cancer cell line panels from Creative Animodel possess identified, well-characterized cancer cell lines with comprehensive mutation data to create powerful tools for cancer research and drug discovery.
What Is Cancer Cell Line Panel Screening?
Cancer cell line panel screening is a high-efficiency anticancer drug screening program based on the use of multiple panels of human solid tumor cell lines. The goal of the program is to evaluate experimental agents or compounds against groups of cell line panels. Each panel (e.g., lung, colon, melanoma, renal, ovarian, and central nervous system) is to contain multiple, representative human tumor cell lines. Drug candidates showing differential or selective patterns of in vitro growth inhibition will be evaluated subsequently in athymic mice bearing the same human tumor cell lines found sensitive in vitro. This approach differs from in vivo screening programs in two fundamental aspects: (a) a single in vivo murine leukemia prescreen step replaced by broad-based in vitro evaluations among a wide variety of cell lines; (b) the major clinical forms of human solid tumors represented by panels of multiple well-characterized human tumor cell lines.
Cancer Cell Line Panel Screening at Creative Animodel
Creative Animodel possesses comprehensive cancer cell lines, covering all the major types of tumors. Our cell lines are from commercial sources such as ATCC, as well as our proprietary PDX-derived primary cancer cell lines. All the cell lines have been tested to be mycoplasma free, and most of our cell lines have been through thorough characterization including seeding densities, determination of cell doubling time, and reference compound testing. Cancer cell line anti-proliferation panel screening is routinely carried out by a dedicated team in our cell culture platform equipped with state-of-the-art instrumentation. Creative Animodel commonly adopts in vitro cell growth or growth inhibition assays (Figure 1) for drug screening. Microculture tetrazolium (MTT) assay and microculture cellular protein assay are available.
Figure 1. Example data. In vitro cancer cell growth inhibition assay of sodium thiosulfate (STS) and compound A. The growth of cancer cells is inhibited with increasing drug concentration. The inhibition rate of STS is better than the compound A.
• Comprehensive cancer cell lines covering different types of cancers
• Experienced industry experts and technical staff
• Cutting-edge technology platforms
• Rapid turnaround time with favorable price
In addition to cancer cell line panel screening, cell services from Creative Animodel include cell viability, cell-based screening and profiling, biomarker studies, functional & cell type specific assays and 3D cell services. We also offer you custom cell services to meet your specific needs. Our company pledges to provide the best experimental design and reliable outcomes to help accelerate your drug research and development. If you have any needs, please feel free to contact us. We look forward to cooperating with you in the near future.