45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052

DMPK

Home / Drug Metabolism & Pharmacokinetics

Drug Metabolism & Pharmacokinetics

Creative Animodel is a leading biotech company specializing in offering set of services for extensive drug metabolism and pharmacokinetic capabilities. Our high-quality data and efficiency of the experimental cycle meet the demands from the early drug discovery to the new drug declaration, acquiring the customer's consistent good comments.

Drug metabolism and pharmacokinetics (DMPK) is the study of drug disposition process in the organism, which use mathematics and dynamics models to describe the process of absorption, distribution, metabolism and excretion (ADME), then combining the exposure of drugs in blood circulation and target organs with clinical manifestations (pharmacodynamics and toxic side effects).

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Figure 1. General paradigm of DMPK screens used in drug development.

In order to reduce the clinical failure of candidates due to the characters as poor PK, instability, low permeability or high toxicity, there have been considerable efforts put into developing in vitro, in vivo and in silico approaches to screening candidates for various DMPK properties. Characterization of ADME profiles is an important part of the selected leads screening, and a completed profile of the candidates’ drug-like properties could be obtained in this step. Meanwhile, the research can be used as a means of ranking compounds for further in vivo studies. The winner of the selection in vitro will play in vivo experiments where the assessment of pharmacokinetics in experimental animals provides the most physiologically relevant preclinical test system which reflects the complexity of all DMPK properties, including PK/PD analysis, compounds distribution, toxicity and safety data. All these pre-screening tests may provide a prediction of what will happen after the candidates applied on the human. And the selected process will benefit the whole drug discovery and development program with less time and costs, but high quality.

Our Services

In Vitro ADMEIn Vivo ADME
Protein Binding AssaysPK/PD Analysis
Metabolic StabilityBioequivalence Studies
Liver Metabolized EnzymesCompound Distribution Assays
Metabolite IDDrug Safety Evaluation
Permeability AssaysPK/PD Study in Animal Disease Models
Sample BioanalysisCassette PK for Compound Screening
 Crossover Studies
 Exploratory Non-GLP TK Studies
 DMPK Study for IND Filing
 Large Molecule PK/BA Services

Creative Animodel could provide all bioanalytical/pharmacokinetic services related to DMPK. Whatever you need whole DMPK screening or part of selected tests for existing candidates, our trained experts are ready to support you with their strong problem-solving skills and expertise. Please contact us to find out more about our services. We look forward to working with you in the future.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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