Creative Animodel provides a wide variety of in vitro systems for metabolic stability studies to help our clients to optimize the bioavailability and duration of drug action of therapeutic candidates thereby increasing their success rate.
Drug metabolism, the enzymatic modification, is a predominant elimination mechanism for most compounds. Metabolic stability refers to the susceptibility of compounds to biotransformation, affecting oral bioavailability and plasma half-life of the compounds. Metabolic stability is a crucial property for both drug administration regiment design as well as toxicity. Notably, it is reported that more than 10% of drug withdrawals from clinical trials result from pharmacokinetic reasons.
Identifying metabolic properties at the early phage is predictive of the human situation, which is very important to specify dose and frequency of administration, and to reduce the possibility of late-stage failure. Metabolic stability assays at Creative Animodel provide a broad range of biological systems to determine the pharmacokinetic parameters of a candidate compound, including intrinsic clearance and half-life.
Metabolic Stability Services:
Creative Animodel provides unparalleled platforms and engages rich-experienced researchers to guarantee metabolic stability studies that add the most scientific value to your drug discovery project.
1. Kola, I. and J. Landis. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov. 2004, 3(8): 711-715.
2. Masimirembwa, C. M., U. Bredberg; et al. Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges. Clin Pharmacokinet. 2003, 42(6): 515-528.