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PD Studies in Animal Disease Models

Creative Animodel offers a complete set of DMPK analysis for our global clients, including in vivo and in vitro experiments. In the aspect of pharmacokinetic/pharmacodynamics (PK/PD) study, we provide normal animal models for PK/PD study as well as disease models such as chronic kidney disease and diabetes. Our central laboratory is fully equipped with the most advanced equipment, network and software infrastructure, outstanding technical support to ensure unparalleled services to our clients.

Why Do We Perform PK/PD Study in Animal Disease Models?

The pharmacokinetic parameters of a drug are obtained from normal human or general patients, and the recommended dose of the drug is also applicable to the general population. However, when the pathological conditions of patients are different (with other complications), processes of the drug in the body absorption, transport, metabolism and excretion will have a certain change. A key rationale for performing PK studies in disease models is to detect these subgroups prospectively.

Animal disease models in the PK/PD evaluation of candidates serve an important role in preclinical assessments of a new drug, dosing optimization for those that are clinically approved, and setting or confirming. The goal of animal model studies is to mimic the diseases in humans to allow for PK/PD studies so that we can find the optimal drug exposures which lead to therapeutic success. The PK/PD index and target drug exposures obtained from validated animal models are critical components in optimizing dosing regimen design in order to maximize efficacy while minimizing the cost and duration of clinical trials.

Examples of PK/PD Studies We Have:
• Renal insufficiency
• Hepatic insufficiency
• Congestive heart failure (CHF)
• Pediatric populations (Non-disease model)
• Elderly populations (Non-disease model)

Types of Animals We Have:

RabbitsDogsPigsSmall RuminatesRodentsNon-human Primate
NZWBeagleYorkshire CrossSheepMiceRhesus monkey
NZW/NZR crossMongrelYucatan MinipigGoatsRatsCynomolgus Monkey
Dutch BeltHoundGöttingen Minipig Guinea Pigs 

Creative Animodel is the top DMPK services provider in the world. We would like to share our experience and resources with you and provide assistance to your research. Our experts will not only resolve your current issue, but will offer guidance on the best way to the possible issue in the future. We sincerely look forward to working with you, please feel free to contact us.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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