45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052


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Pharmacokinetics Studies

Creative Animodel has a contract development team supporting biopharma companies in all phases of product development across all the therapeutic areas. We blend science with people and technology to help global clients to accelerate drug discovery and development across small and large molecule platforms. With over 10 years of specialized experience, our pharmacokinetics services are designed to provide fast-turnaround and low cost studies with clear and frequent clients communications.


Pharmacokinetics (PK) is the study of the time course of a drug within the body and incorporates the processes of absorption, distribution, metabolism, and excretion (ADME). It is the study of the spatial and temporal distribution of an administration drug. In general, pharmacokinetic parameters are derived from the measurement of drug concentrations in blood or plasma. Plasma is the traditionally sampled matrix due to convenience and the concentrations in the circulation will be in some form of equilibrium with the tissues of the body. However, drug molecules may be bound to a greater or lesser extent to the proteins present within the plasma; thus, free drug levels may be vastly different from those of total drug. Because of analytical difficulties (separation and sensitivity), it is usually the total drug that is measured and used in pharmacokinetic evaluation. Such measurements and analysis are adequate for understanding the drug within a single species in different situations since protein binding and resultant unbound fraction is approximately constant under these conditions.

Pharmacokinetics Studies at Creative Animodel

Creative Animodel provides sensitive, high throughput evaluation of drug concentration in a variety of matrices including serum, plasma, urine, and saliva. Our analytical and bioanalytical laboratories contain GLP-compliant systems and state-of-the-art equipment, including multiple LC/MS/MS systems as well as immunoassay technical platforms. Our scientists are experienced in supporting pharmacokinetics assessments in a variety of animal species including rodents, non-rodents, as well as non-human primates. We are well-versed with the factors that could influence the validity of the data during pharmacokinetics analysis, and take those complexities into account during method validation to ensure optimal results.

Our Advantages:
• Multiple animal species including non-human primates.
• Various administration routes (iv., po., ip., sc., im., etc.)
• Advanced facilities, technical platforms and optimized methods.
• Comprehensive reports (Cmax, tmax, t1/2, AUC0-t, AUCinf, CLtot, Vdss, BA/EA, etc)
• Customized services can be tailored to customers’ specific requirements.
• Fast turnaround time and low cost.

Quantitative measurements of pharmacokinetics provide valuable information on the bioavailability/bioequivalence of your compounds and they are essential for the design of preclinical pharmacological and toxicological studies. Creative Animodel leverages our extensive expertise and integrated techniques to provide a broad spectrum of high quality pharmacokinetics services. If you have any additional requirements or questions, please do not hesitate to contact us.

Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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