NHP Disease Models
Creative Animodel develops a series of animal disease models for distinct in-vivo tests including drug toxicology and safety, PD/PK, disease pathogenic mechanism and therapeutic studies. NHP models can be customized based on requirements or established protocols. Creative Animodel fully understands animal research is a time-costing process. To serve customers better, our professional group can efficiently deliver animal disease models to assigned institute or conduct preclinical projects for clients.
Non-human primates, in genetic and physiological aspects, are more advanced in preclinical efficacy and toxicity tests. Creative Animodel has the expert personnel and enriched NHP resources for developing carcinogen-induced NHP tumor models, as well as infection-associated cancer models.
• Cardiovascular Diseases
NHP cardiac disease models offer advanced platforms to discover novel and efficient therapeutic approaches for cardiovascular diseases. We provide NHP services related to cardiac arrhythmias, atherosclerosis and myocardial ischemia/infraction reperfusion.
• CNS Diseases
Due to the complexity of neuroscience studies, animal experiments have an advantage of providing more physiological responses than in vitro and computer models. NHP models are more applicable for their similar aging process to human. Central Nervous System (CNS) diseases models developed in Creative Animodel are perfect choices for neurological disorder researches. We provide cognitive, behavioral, imaging and in vivo analyses for CNS disorders including Alzheimer’s disease, Huntington’s disease and Parkinson’s disease.
• Infectious Diseases
Creative Animodel fully understands difficulties of developing infectious diseases models carrying human immune cells in small animals. We proudly provide our clients with popular NHP research models including malaria, HIV/AIDS and Tuberculosis.
• Metabolic Disorders
Small animals like rodent are most commonly used model for studying metabolic syndromes, however, NHP has superior advantages in these areas, in aspects similar fat deposit mechanism (adipocytes proliferation) and biological characters to human. We offer NHP metabolic models including Type I&II diabetes and obesity.
• Ocular Disease
Primates are the only animals with the closest ocular structure to human, while primate has advantages of bigger ocular size than other animal models and has macula in the retina, which is the major researching site of diabetic retinopathy, glaucoma, choroidal neovascularization.
• Reproductive Biology and Diseases
Primates and human share similar histological structure of fallopian and same pregnancy pattern (fertilization and position of embryo into uterus). Some old world monkey species such as rhesus, cynomolgus and Japanese macaques can display menstrual period and menopause like human. Creative Animodel provides clients with the most reproductive NHP services for a better understanding of human reproductive disorders, including Endometriosis, Polycystic Ovary Syndrome (PCOS) and Pelvic inflammatory diseases (PID).
Creative Animodel always stays with you for every progress you made. Our expert personnel are very experienced in designing, conducting and interpreting NHP related projects. We also can perform drug or new compound safety tests in these models. Please contact our customer service for more information.