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Alzheimer's Disease Models

Creative Animodel offers an extensive portfolio of both in vitro and in vivo services in pharmacology and toxicology. Our rich-experienced scientists and state-of-art technique platforms assist the clients throughout every stage of the drug discovery process. We are now providing professional Alzheimer’s disease models to advance the understanding of pathology and discover effective therapeutics that prevent the neurodegenerative processes.

Alzheimer’s Disease: Symptoms and Pathology

Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that affects approximately 29.8 million people worldwide. It is the most common age-associated neurodegenerative disease, characterized by dementia and progressively worsening impairments to learning ability and memory skill, accompanied by a plethora of changes in personality, behavior, sleeping patterns, and functionality. Familial “early onset” (beginning in the third decade of life) of AD is rare, and almost all cases are considered “late onset” (>65 years); nevertheless, both diseases present with similar neurological and pathological traits.

The main pathologies that characterize AD include intracellular and extracellular aggregates of a small protein called amyloid beta (Aβ), generally referred to as senile plaques, and intracellular neurofbrillary tangles (NFTs) caused by aggregates of hyperphosphorylated tau protein. It is speculated that these toxic agents inhibit neural activity, induce neuronal cell death, and promote synaptic and dendritic loss. There also appears to be a strong link between noradrenergic degeneration, neuroinflammation, increased glial activation, and compromised serotonergic function with classic AD pathology. Lastly, the APOE ε4 genotype and TREM2 mutants have also been implicated as risk factors to AD.

Alzheimer’s Disease Models at Creative Animodel

Current therapies for AD mainly aim to inhibit the phosphorylation of tau protein, or reduce the level of Aβ peptides. However, few compounds show significant benefits in clinical trials. As part of our neuroscience portfolio, Creative Animodel offers a variety of AD models and related services that allow screening of novel drug candidates.

Tg2576 mouse models:
overexpressing a mutant form of amyloid precursor protein (APP), linkeds to early-onset familial Alzheimer’s disease (AD), developing significant amyloid plaques and displaying progressive memory deficits.
Tau P301S mouse models:
Carrying human P301S mutation of microtubule-associated protein tau gene (MAPT), they develop into NFT and demonstrate signs of age-associated cognitive impairment and motor deficits.
Aged rodents:
aging is an important factor of cognitive decline and AD within the human population. Aged rodents (rats and mice) with memory deficits display pathological and behavioral features common to AD.
Scopolamine-induced amnesia models:
Cholinergic system is deeply involved in memory function, and cholinergic deficiency in AD is a crucial contributor to produce dementia. Scopolamine is a muscarinic cholinergic receptor antagonist which leads to reduced cholinergic transmission, and further causes learning and memory dysfunction in humans and other animal species. Creative Animodel offers scopolamine-induced amnesia models established on adult young or aged rodents to meet different needs.

Model Characteristics and Pharmacology Evaluation
• Behavioral and cognitive tests: open field test and contextual fear conditioning test
• MRI and IHC imaging including relevant biomarkers
• Aβ measurement: soluble and insoluble

Creative Animodel offers end-to-end validated pre-clinical models and related services of pharmacology and toxicology. We support the global clients in model establishment, imaging modalities, behavioral tests as well as biomarker endpoint assays to help identify novel therapies for AD and other neurodegenerative diseases. Please feel free to contact us for more information.

References:
1. Hau J, Schapiro SJ. Handbook of Laboratory Animal Science, Volume II, Third Edition: Essential Principles and Practices: CRC Press, 2010.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-207-8356 1-631-871-5806 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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