Based on our diverse dermatological models, a package of in vivo pharmacology services is provided to accelerate the process of your new drug discovery and development.
Overview of Skin
Considered as our largest organ, skin covers our body and has a surface area of 1.5 - 2.0 m2. Healthy skin is important for both the appearance and functions. It provides protection as a physical barrier, maintains water, regulates body temperature, synthesizes Vitamin D, and allows sensations of touch and temperature changes.
The skin consists of three layers: epidermis, dermis, and hypodermis (also called subcutaneous tissue). The outermost layer refers to the epidermis that is formed by keratinocytes. The basic function of keratinocytes is to synthesize a filamentous protein, i.e., keratin. The middle layer is dermis with the fibrillar structural protein collagen as its main component. Situated on the top of the subcutaneous tissue, the hypodermis, the innermost layer of skin, is composed of lobules of lipocytes.
The complexity of dermatology can not currently be replicated by in vitro models, and thus the use of animal models is demanded. Creative Animodel offers a wide spectrum of animal models of wound healing and psoriasis in both rodents (for earlier research) and pigs (for drug efficacy studies).
Dermatological Models at Creative Animodel
Wound Healing Models
Wound healing represents a morphogenetic response to trauma or injury, which is classified into acute wound healing and chronic wound healing. Understanding wound healing helps the treatment development in all fields, such as cancer and diabetes. We establish wound healing models in both rodents and pigs with thermal, mechanical, or chemical methods. And the wound types include sunburn, thermal burn, diabetic wound, laser resurfacing, surgical suturing with tension, pigmented skin wound, etc.
Psoriasis is a long-term and persistent inflammatory skin disease characterized by the patches of abnormal skin. Psoriasis is caused by increased number of immune cells that generate vast amounts of cytokines, chemokines, and inflammatory molecules. We provide an integrated portfolio of psoriasis models, including imiquimod (IMQ) induction in wild-type mice and human transgenic mice, as well as immunomodulator induction in immunocompetent rodent species.
Passive Cutaneous Anaphylaxis Models
Passive cutaneous anaphylaxis (PCA) is an immediate dermal response mediated by the cross-linking of allergens to IgE on the surface of mast cells and basophils. It belongs to type I hypersensitivity reaction and is characterized by increased permeability of vessels within the skin. Creative Animodel provides both murine models of PCA and pharmacological service to understand the dermal sensitivity to allergens and drug efficacy in hypersensitivity reaction.
• Various preclinical models for dermatology
• Integrated measurement and evaluation package
• Statistical analysis of drug efficacy data
Creative Animodel has spent decades of efforts to provide specialty pharmacology services in human diseases. Our state-of-the-art facilities and profound pharmaceutical knowledge enhance our capabilities to optimize and exploit disease models to advance the pharmaceutical industries. We will be appreciated to be your partner to make a contribution to human health together. Looking forward to cooperating with you in the near future.