Digestive diseases, also known as gastrointestinal (GI) diseases, are characterized by disorders in GI tract involving the esophagus, stomach, liver, gallbladder, pancreas, small intestine and large intestine. They can arise from numerous causes either directly or indirectly, such as infections, diet, smoke, lifestyle, stress, and drugs. Some digestive diseases are acute, lasting only a short time, while others are chronic, or long-lasting. The first is an early vascular lesion that manifests as mild changes in intestinal permeability, transport, and absorption, which always leads to anemia or dyslipidemia. This stage is followed by neural dysfunction, in which the patients start to have clinical symptoms such as dysphagia, gastroesophageal reflux (GER) and bloating. Digestive diseases account for 10% of annual mortalities in the United States, and approximately 70 million Americans experience gastrointestinal illness each year, with colorectal cancer as the leading cause of mortality in adults from digestive disease.
Animal models are of great importance to understand the mechanisms of digestive diseases and explore the effective therapeutics. With years of expertise, Creative Animodel has successfully established a variety of professional animal models to help our customers advance their drug development.
Creative Animodel has spent years of efforts to optimize and bring specialized digestive disease models to our global customers. We have unparalleled platforms and rich experience to guarantee high-quality services with low cost and rapid turnaround time. If you have any questions, please feel free to contact us.