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Digestive diseases

Digestive diseases, also known as gastrointestinal (GI) diseases, are characterized by disorders in GI tract involving the esophagus, stomach, liver, gallbladder, pancreas, small intestine and large intestine. They can arise from numerous causes either directly or indirectly, such as infections, diet, smoke, lifestyle, stress, and drugs. Some digestive diseases are acute, lasting only a short time, while others are chronic, or long-lasting. The first is an early vascular lesion that manifests as mild changes in intestinal permeability, transport, and absorption, which always leads to anemia or dyslipidemia. This stage is followed by neural dysfunction, in which the patients start to have clinical symptoms such as dysphagia, gastroesophageal reflux (GER) and bloating. Digestive diseases account for 10% of annual mortalities in the United States, and approximately 70 million Americans experience gastrointestinal illness each year, with colorectal cancer as the leading cause of mortality in adults from digestive disease.

Animal models are of great importance to understand the mechanisms of digestive diseases and explore the effective therapeutics. With years of expertise, Creative Animodel has successfully established a variety of professional animal models to help our customers advance their drug development.

Gastric Disease
Gastric diseases refer to diseases affecting the stomach which might cause the symptoms including dyspepsia, vomiting, and gastric acid secretion, gastric ulcers, as well as malnutrition. Creative Animodel provides both gastric acid secretion models and gastric ulcers models to help our customers elucidate the mechanisms of gastric diseases and develop effective drugs.
Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a group of inflammatory conditions along the gastrointestinal tract, mostly seen in colon and small intestine. It is a complex disease which arises as a result of the interaction of environmental and genetic factors leading to immunological responses and inflammation in the intestine. Creative Animodel provides a wide range of professional IBD models to promote your drug development.
Liver Disease
Liver disease refers to a type of disease that causes damages to the liver tissue and many relevant physiological functions. The etiologies of liver disease are extremely diverse, varying from autoimmune disease, viral infections, and imbalanced diets to intoxications. Creative Animodel has successfully established two well-characterized liver disease models: Non-alcoholic fatty liver disease (NAFLD) models and liver fibrosis models, which are useful tools to evaluate the efficacy and safety for your drug candidates.

Creative Animodel has spent years of efforts to optimize and bring specialized digestive disease models to our global customers. We have unparalleled platforms and rich experience to guarantee high-quality services with low cost and rapid turnaround time. If you have any questions, please feel free to contact us.

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