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Dyslipidemia and Atherosclerosis Models

Creative Animodel is a preclinical biopharmaceutical company that offers outstanding pharmacology consultancy and research services, and specializes in metabolic disorders such as diabetes, obesity, dyslipidemia, atherosclerosis and cardiovascular complications. Our staffs are led by senior scientists with rich international drug discovery experience, enabling the high-quality data with competitive price and fast turnaround time.

The Relationship Between Dyslipidemia and Atherosclerosis

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Atherosclerosis is a multifactorial disease composed of a multitude of pathogenic developments, including macrophage foam cell formation and death, accumulation of extracellular lipid, chronic inflammation and the proliferation of intimal smooth muscle cell creating a fibro-fatty plaque. Those soft plaques could suddenly rupture with the subsequent transformation to thrombus that rapidly slow or stop blood flow, leading to a heart attack, stroke or a sudden cardiac death. A number of genetic and environmental factors contribute to its development.

Dyslipidemia, a major risk factor for atherosclerosis and consequent cardiovascular disease (CVD), is a disorder of lipoprotein metabolism, including lipoprotein overproduction or deficiency. Dyslipidemia, along with insulin resistance, obesity and type 2 diabetes, comprises an important component of the metabolic syndrome. Numerous epidemiological and clinical studies have identified that there is a strong association between certain types of dyslipidemia (such as hypercholesterolemia, hypertriglyceridemia, combined hyperlipidemia, phytosterolemia, etc.) and development of atherosclerotic lesions.

Atherogenic dyslipidemia has emerged as an important risk factor for myocardial infarction and cardiovascular disease, which constitutes a public health problem in terms of the cost for society and the quality of life for patients. Many clinical and experimental attempts have been made to understand the pathophysiology of this disease.

Dyslipidemia and Atherosclerosis Models at Creative Animodel

With state-of-the-art facilities, our experienced scientists have successfully established a range of dyslipidemia and atherosclerosis models to mimic the human condition, analyze pathogenesis, and evaluate the efficiency of your drug candidates.

• High-Cholesterol Diet (HCD) Model    
HCD is widely used in dyslipidemia and atherosclerosis animal studies. HCD can increase the concentration of pro-atherogenic lipoproteins in the blood. We provide the well-characterized dyslipidemia and atherosclerosis model via feeding animal with HCD. This model has lots of similarities to human atherosclerosis in terms of the disease course and progression.

• Transgenic Models    
Gene manipulation has been used to increase sensitivity to cholesterol in mice and rat. Creative Animodel uses transgenic technology to generate a number of genetically modified models, which show atherosclerotic changes in the aorta resembling human disease. We have various transgenic models including ApoE-KO model, LDLR-KO model and PCSK9 model to help you evaluate the efficiency and safety of your drug candidates.

Creative Animodel has a team of scientists skilled in animal model generation and preclinical in vivo drug trials. We work closely with our partners to identify, design and execute joint research activities more efficiently and more strategically so that milestones are met as quickly and efficiently as possible. If you have any questions, please feel free to contact us.

References:
1. Russell J C, Proctor S D. Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosis. Cardiovascular Pathology, 2006, 15(6): 318-330.
2. Tailleux A.; et al. Murine models to investigate pharmacological compounds acting as ligands of PPARs in dyslipidemia and atherosclerosis. Trends in pharmacological sciences, 2003, 24(10): 530-534.
3. Getz G S, Reardon C A. Animal models of atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 2012, 32(5): 1104-1115.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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