HSV Latency Mouse Models
Creative Animodel is a leading biotech company focusing attention on in vivo pharmacology researches all the time. With years of expertise, we can offer herpes simplex viruse (HSV) latency mouse models for screening, testing and evaluation of new drugs and formulations.
What Is HSV-1 Latency?
HSVs are members of the Alphaherpesvirinae subfamily under the Herpesviridae virus family. There are two serotypes of HSV: HSV type 1 (HSV-1), which is more frequently found in the oral mucosa and ocular areas, and HSV type 2 (HSV-2), which is most commonly encountered as the causative agent of genital tract HSV infections. HSV is a ubiquitous human pathogen, with worldwide prevalence rates approaching 90% for HSV-1 and up to 25% for HSV-2. HSV-1 is remarkable in its ability to establish a lifelong latent infection in human hosts following exposure to the virus. After initial infection, HSV-1 travels by retrograde axonal transport to sensory ganglia to establish latency. Latency of HSV-1 occurs in the superior cervical ganglion (SCG) and trigeminal ganglion (TG), ciliary ganglion, nodose ganglion, otic ganglion, pterygopalatine ganglion, submandibular ganglion, geniculate ganglion, ophthalmic branch of the trigeminal nerve, and root entry zone of the trigeminal nerve into the brainstem. Latent HSV-1 has also been described in other nonneuronal tissues, such as the cornea.
Our HSV Latency Mouse Models
Mice are widely used to study HSV-1-induced immune responses because their genetic systems have been well characterized; immunologic and molecular biologic reagents are widely obtainable; and the number of genetic knockout strains available for analysis is greater than for other species. HSV-1 reproducibly establishes latency in the mouse model during the earliest stages of acute infection, with the viral genome reaching the neuronal ganglia in the first 24 h of infection.
Creative Animodel has extensive experience to establish HSV latency mouse model (Ganglion Explant Model). HSV-1 is one of the most common causes of infectious human blindness in the developed world; therefore, viral pathogenicity of ocular tissue is an area of intensive research interest. We isolate HSV-1 from the eyes of latently infected mice and the infectious HSV-1 is detected earlier from trigeminal ganglia (TG) culture. Relying on our animal models, we offer a full range of test services to help evaluate the efficacy of your drug candidates in HSV-1 disease.
Our Service Platform
• Compound screening
• Dose response assays
• HSV reporter assays
• Analyses of HSV related mRNA expression
• Viral genome load and virious production assays
• Seasoned managements and well-experienced research teams
• Outstanding infrastructures and instrumentation
• High-level customer satisfactions and flexible collaboration models
Creative Animodel has experienced experts in the field of preclinical drug evaluation. Our model selection in each disease area is based on clinical relevance and is defined. Our mission is to deliver high-quality image and reliable data accurately and efficiently to further optimize drug development process. Creative Animodel is the best partner for your drug discovery.
1. Kollias C M.; et al. Animal models of herpes simplex virus immunity and pathogenesis. Journal of Neurovirology. 2015, 21(1):8.