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Inflammation

Creative Animodel, as a leading company in the field of new drug discovery and development, provides the whole determination of in vitro and in vivo to investigate the efficacy, mechanism of action and toxicity of new compounds. We have wild range types of human disease models from cardiovascular disease to genitourinary disease, multiple animal species covering from rodent to non-human primate and complete technical platforms. All these advantages guarantee our services are reliable and prompt. And we have the capacity of accelerating the process of your research in inflammation.

Inflammation is a protective response of body tissue faced to harmful stimuli, and this process is complex which usually involves immune cells, blood vessels, and molecular mediators. When inflammation occurs, chemicals from the body's white blood cells are released into the blood or affected tissues to protect your body from foreign substances. This release of chemicals increases the blood flow to the area of injury or infection, and may result in redness and warmth. Some of the chemicals cause a leak of fluid into the tissues, resulting in swelling. This protective process may stimulate nerves and cause pain.

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Figure 1. Cellular components of inflammation.

The function of inflammation is to eliminate the initial cause of injury, clear out necrotic cells and tissues damaged, and then initiate tissue repair. Typical symptoms of inflammation include redness, pain, swollen joint or stiffness and even loss of joint function.

The Differences Between Acute Inflammation and Chronic Inflammation

There are two types of inflammation. Acute inflammation starts rapidly (rapid onset) and is the initial response of the body to harmful stimuli. Signs and symptoms won't be present for a long time. On the contrary, chronic inflammation, the long-term inflammation, can last for several months and even years, that is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.

Table 1. Features of acute and chronic inflammation.

FeatureAcuteChronic
OnsetFast: minutes or hoursSlow: days
Cellular infiltrateMainly neutrophilsMonocytes/macrophages and lymphocytes
Tissue injury, fibrosisUsually mild and self-limitedOften severe and progressive
Local and systemic signsProminentLess prominent; may be subtle

There are many factors that will result in inflammation. Generally, bacterial infection and environmental allergen will induce acute inflammation (including some kinds of anaphylactic reaction). Meanwhile, long-term health problems and lifestyle choices, such as smoking and drinking alcohol, virus infections, and unbalanced diets may cause a chronic inflammation. In addition, autoimmune disorders also belong to chronic inflammation.

We categorized the diseases models based on different causes:

By autoimmune disordersBy infections By other reasons
Auto-immune Hepatitis ModelsLPS Acute Response Models Mucositis Models
Allergic Rhinitis Models            Asthma models Gouty Arthritis Models
Multiple Sclerosis Models Passive Cutaneous Anaphylaxis (PCA) Models Radiation Syndrome Models
System Lupus Erythematosus (SLE) ModelsPulmonary Fibrosis ModelsGraft-Versus-Host Disease (GVHD) Models
Rheumatoid Arthritis ModelsInflammatory Bowel Disease Models 
Delayed Type Hypersensitivity (DTH) Models Antibacterial Models 
Experimental Autoimmune Neuritis (EAN) Models Cough Models 
Experimental Autoimmune Uveoretinitis (EAU) Models Sepsis Models 

Creative Animodel has rich experience of new drug discovery and development. We devote to helping make a success of your project by providing a comprehensive and immediate communication with project scientists, and a prompt turn-around time for information and data. If you have any questions or specific needs, please don’t hesitate to contact us. We look forward to cooperating with you.

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