Creative Animodel is a global leader in in vitro drug screening and profiling with a comprehensive offering of services designed to shorten and simplify your drug discovery study. With rich-experienced scientists and state-of-the-art technique platforms, we can provide a broad portfolio of both binding and functional assays for ion channels.
Ion Channels in Diseases and Drug Discovery
An ion channel is a gated and water-filled pore created by transmembrane proteins to help establish and control voltage potential across cell membranes by controlling the active flow of ions between the intracellular and the extracellular environments. The ion channel family is intimately involved in almost all aspects of physiology and plays a critical role in diverse processes such as nerve and muscle relaxation, cognition, regulation of blood pressure, sensory transduction, and cell proliferation. Their modulation has been linked to a broad range of diseases that include cardiac disorders, kidney failure, neurological indications, the perception of pain, and blindness. Over 60 “channelopathies” have been identified as human diseases that are brought about through mutations in ion channels. Given the central functional role that the ion channel superfamily plays in human physiology, its membrane localization, and the diverse tissue distribution of different members of ion channels family, it represents an attractive potential target class for drug discovery.
Ion Channel Screening & Profiling Services at Creative Animodel
Over ten years’ experience as an ion channel CRO has enabled us to better understand our customers' latent needs. Our scientific experts are ready to reduce the risk and maximize the success of your discovery programs. Our services include but are not limited to:
• Ion channel binding assays
Our binding assay utilizes the gold standard filtration method to produce highest assay robustness. Ion channel binding assays are conducted with membrane preparations produced in-house to control for the quality of these critical reagents and to ensure tight data reproducibility. Radioligand binding assays are a useful method for monitoring potential hERG liability at the earliest phase of drug discovery.
• Ion channel functional assays
Creative Animodel provides a wide range of functional assay services, including flux-based assays, manual patch clamp assays, fluorescence-based assays, automated electrophysiological assays and microelectrode array assays. From single-cell manual patch clamp to high throughput 384-well automated electrophysiology instruments, we use our cells on several different platforms to provide the throughput or depth of analysis that meet your demands.
• Human cardiomyocytes cardiotoxicity services
Cardiotoxicity is a major cause of drug development failure and withdrawals. The human ether-a-go-go related gene (hERG) screening alone can’t reliably detect potential cardiac adverse side effects. To better predict proarrhythmic risks using in vitro assays, a comprehensive in vitro proarrhythmia assay (CiPA) has been proposed. Creative Animodel provides complimentary approaches, including Multiple Electrode Array (MEA), High Content Analysis (HCA) and manual patch clamp assays, to reliably detect and characterize cardiac safety risks.
Creative Animodel can provide our customers the comprehensive services and highest quality results of ion channel screening & profiling assays. With the help of our talented scientists, we are confident in accelerating your project progress and achieving ideal research goals with the most competitive price. If you have any special requirements, please feel free to contact us. We look forward to working together on your attractive projects.
Bagal S K, et al. Ion channels as therapeutic targets: a drug discovery perspective. Journal of Medicinal Chemistry. 2013, 56(3):593-624.