45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052

Pharmacology

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Keratitis Models

Creative Animodel is a professional provider that focuses on in vivo pharmacology. With over 10 years of specialized experience, we offer comprehensive services based on multiple keratitis models to meet your project needs, which helps investigate the new drugs’ efficacy and safety.

What Is Keratitis?

Keratitis, a disease of the cornea, can result from direct infection with viruses, bacteria, fungi and amoebae or from immune-related complications such as the sterile keratitis associated with Lyme disease. Keratitis can progress rapidly with corneal destruction through pathological wound healing within 24-48 hours. A decade-old estimate for keratitis induced corneal ulcers of approximately 2 million per annum in the developed world is likely to be conservative. Permanent visual dysfunction has been reported in a significant number of patients in both developed and developing nations.

Microbial keratitis is an infectious disease of the cornea that is characterised by inflammation, often with stromal infiltration by leukocytes. Initial management of microbial keratitis is empiric with broad-spectrum topical antimicrobials, as with current microbiological investigations, it can take days or even weeks to identify a causative organism. This reliance on antimicrobials has been implicated in the emerging resistance in some countries to some of these commonly used antimicrobial agents. Furthermore, topical therapy has limitations, including their rapid loss caused by drainage, high tear turnover and ocular toxicity. Patients with microbial keratitis continue to lose vision and suffer ocular pain and discomfort. Clearly, improved therapies for microbial keratitis are required.

Our Keratitis Models

Creative Animodel has developed a series of keratitis models to analyze the disease from both the microbial and the host aspects. The use of animal models has contributed to the understanding of the pathology and the discovery of more effective treatments that may prevent corneal damage.

Bacterial Keratitis Models: Creative Animodel provides keratitis models inducing Pseudomonas and Staphylococcus keratitis in rabbits and mice according to customers’ needs. The clinical observations of our bacterial keratitis models are very similar to human keratitis symptoms, such as cornea pain, redness, inflammation and opacity.
Acanthamoeba Keratitis Models: Acanthamoeba keratitis (AK), a painful and potentially blinding infection of the cornea, has been reported to be caused by Acanthamoeba species. We establish animal models of AK in rabbits by micro-injection of Acanthamoeba healyi trophozoites between the corneal epithelium and Bowman’s layer (anterior to the corneal stroma). Our method is designed to allow slow infiltration of the protozoa, which may simulate a natural disease course in humans.
Fungal Keratitis Models: Aspergillus (Aspergillus flavus, Aspergillus fumigatus) and Fusarium (Fusarium solani, Fusarium oxysporum) species are the main etiologic agents of fungal keratitis. We have developed mouse models of Aspergillus and Fusarium keratitis through the inoculation of fluorescent-labeled fungi into the cornea. Our models facilitate the accurate identification and screening of fungal infections during the early stages of fungal keratitis and provide a novel and reliable technology to study the fungal keratitis.

Creative Animodel provides the most reliable and efficient services to meet customers’ needs. Our scientists have rich experience and capabilities in pharmacology to develop disease models to help our clients solve their research problems. If you have any questions or other requirements, please feel free to contact us.

Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-614-7828 1-631-372-1052 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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