Creative Animodel is a professional contract research organization offering kinase screening and profiling for kinases based drug discovery. With years of experience in kinase screening and profiling, we offer our clients professional and reliable information to accelerate the process of kinase drug discovery.
What Are Kinases?
A kinase is a kind of enzyme that catalyzes transfer of phosphate groups from high-energy, phosphate-donating molecules like ATP to specific substrates, and this process is called phosphorylation. Involving in cell signaling, metabolism, cellular transport, protein regulation and other cellular pathways, kinases are very important for human physiology. More than 500 different kinases are coded by human genome, which can be classified into seven groups. Kinase is one of the most important target families in drug discovery, and constantly treats as an popular area of interest of pharmaceutical industry and academia. Inhibitors of kinases can dampen hyperactive processes which would be important treatments for human diseases. It is reported that there are 30 kinase inhibitors approved by FDA, which increases interests of kinases as a drug target class.
Figure 1. A structural view of protein kinases specificity determinants. (Bórquez D. A., 2016)
Kinase Services at Creative Animodel
In order to understand structure/activity relationships, avoid targets with toxic liabilities and select satisfying drug candidates, it is essential to conduct a wild range of screening and profiling for new kinase inhibitors programs. We provide biochemical assays and cell-based assays for your kinase based drug discovery.
• Biochemical assays.
Biochemical assays include two classes: activity assays and binding assays. We can offer different kinase assay platforms based on clients’ needs, including radioisotope filter binding, scintillation proximity, fluorescence resonance energy transfer (FRET), time-resolved fluorescence resonance energy transfer (TR-FRET), luminescence detection, mobility shift and competition binding.
• Cell-based assays.
The cell-based data offers a more comprehensive view of biological context and resulting cellular responses, allowing for more informed decisions to be made about which compounds advance and which one need to be cut out. We provide a growing menu of homogenous, functional assays to detect activated kinases in whole cells, including activity evaluation services, compound binding assay, protein interaction detection, cellular selectivity screen and compound screening, etc.
• Nearly 500 kinases to help clients to conduct kinase screening and profiling for selectivity testing.
• Deliver reliable results in a rapid timeline to assist clients with getting data quickly.
• Use a cutting-edge compound management system to provide high-quality data for every project.
Creative Animodel provides high-quality kinases services. Our professional and experienced experts will work closely with you to support your compounds screening and profiling. Our services are highly flexible addressing your special demands on kinase drug discovery. If you have any questions or specific needs, please feel free to contact us.
1. Bórquez D. A.; González-Billault C. Bioinformatics approaches for predicting kinase–substrate relationships. Bioinformatics-Updated Features and Applications. InTech, 2016.
2. Martić S.; Kraatz H. B. Chemical biology toolkit for exploring protein kinase catalyzed phosphorylation reactions. Chemical Science. 2013, 4(1): 42-59.