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Lung Inflammation Models

Creative Animodel is an ideal partner in in vivo pharmacology researches during the drug discovery and development process. With years of dedication, our scientific team has accumulated rich experience and set up multiple state-of-the-art technical platforms for animal modeling and preclinical studies. We currently offer professional models of lung inflammation and related services.

Overview of Lung Inflammation

Lung diseases are some of the most common global medical problems, in which lung inflammation is the basis for the majority of both acute and ongoing lung conditions. Acute lung injury is a rapid inflammatory response occurred in the lung and can be caused by numerous external factors that can reach the lung via the airways or through the blood circulation. Acute inflammation is an important form of innate immune defence to protect the host from systemic infection and help to restore tissue homeostasis. It is largely mediated by granulocyte effector cells such as neutrophils and eosinophils.

Failure to remove these cells, therefore, can lead to robust numbers of infiltrating activated granulocytes in the injured site, which in turn progresses to chronic inflammation. Lung inflammation is a critical component of many chronic pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis.

The resolution of lung inflammation has been identified as an active and highly regulated cellular and biochemical process. The attenuation of pro-inflammatory mediators, activation of endogenous anti-inflammatory lipid mediators, phagocytic clearance of apoptotic cells, phenotype switching of inflammatory cells from pro- to anti-inflammatory status and lung mucociliary clearance of infective factors assist in the successful resolution of lung inflammation.

Lung Inflammation Models at Creative Animodel

An important goal in pharmaceutics is to achieve anti-inflammatory strategies by blocking or suppressing specific cytokines and chemokines that trigger and amplify lung inflammation. Creative Animodel establishes lung inflammation models induced by LPS or tobacco smoke.

PS-induced lung inflammation
LPS-induced inflammation is the most frequently used model simplified for acute lung injuries. It is usually employed to study pulmonary response to a selected bacterial ligand. Intranasal administration of LPS initiates a pro-inflammatory response in the lungs, recapitulating aspects of the inflammatory cascades that are associated with inflammatory lung disease in humans.
Tobacco smoke-induced lung Inflammation
Cigarette smoke leads to inflammation in the lung and is the main cause for COPD. Generally, individuals are exposed to mainstream (or first hand) smoke, sidestream (or second hand) smoke, or both. Thus, Creative Animodel provides different animal models for specific applications: only the nose or the whole body of the animal is exposed to cigarette smoke in a smoking apparatus for mainstream or sidestream studies respectively.

Creative Animodel is developing models of lung inflammation in mice, rats or non-human primates, allowing the examination of both small molecular and biological compounds that may disrupt the inflammatory cascades and attenuate or abort the disease process. We are the best in scientific knowledge, expertise, data quality, timelines, flexibility and personal contacts. If you have any questions, please feel free to contact us.

1. Leberl M, et al., Tobacco smoke induced COPD/emphysema in the animal model—are we all on the same page?. Frontiers in physiology, 2013, 4:91
2. Knapp S. LPS and bacterial lung inflammation models. Drug Discovery Today: Disease Models, 2009, 6(4): 113-118.

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Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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