Creative Animodel offers pharmacology services based on pre-clinical models of human diseases to evaluate the efficacy and safety of new drugs before the clinical trials. We provide comprehensive support covering from model selection, assay performing to statistical analysis and data delivery. Our rich experience and high-quality data delivery have a great reputation worldwide.
Overview of Mucosal & Mucositis
Mucosal tissue, also known as mucosa or the mucous membrane, is membrane lining all body passages which communicate with the air, such as the respiratory and alimentary tracts. And it consists of cells and associated glands which can secrete mucus.
Mucositis is the painful inflammation and ulceration of the mucous membranes. It can occur anywhere along the mucous membranes, including gastrointestinal (GI) tract, oral and genitourinary tract. Usually, mucositis occurs as a side-effect of chemotherapy and radiotherapy treatment for cancer.
Mucositis is arising in 60% of cancer patients treated with chemotherapeutic agents or radiotherapy. This condition results from the inhibitory effects of chemotherapy on DNA replication and mucosal cell proliferation. This direct inhibition causes histological changes in the GI tract which includes apoptosis, crypt cell hyperproliferation, villous atrophy, collagen breakdown, ulcerated lesions and increased intestinal permeability. GI tract mucositis always induces abdominal bloating, pain, nausea, diarrhea and weight loss. The symptoms of oral mucositis include the mucosal lining of the mouth becomes thin even slough off, become red, inflamed, and ulcerated. Oral mucositis can accompany with severely painful and the degree of pain is usually related to the extent of the tissue damage.
Figure 1. Diagram of the mucositis' pathobiology. (Sonis, 2004)
Mucositis Models Provided by Creative Animodel
Rodent is a frequently used model for investigation of cancer-therapy-induced mucosal injury, such as mice, rat, hamster, etc. And we provide multiple methods to establish the models, including acute radiation, fractionated radiation, chemo-radiation, and chemotherapy.
In addition to above models, we also have an evaluation package:
• Daily metabolic data: body weight, food and water intake, faecal and urine output
• Mucositis scoring: scale from 0–10, score draw on each parameter including body weight loss, rectal bleeding, stool consistency and general condition of the animal
• Tissue collection and histological analysis
• Statistical analysis
Creative Animodel dedicates to providing our global clients with special pharmacology services in human diseases. We have the state-of-the-art facility and profound pharmaceutical knowledge and both of which enhance our capabilities to advance the development of pharmaceutical industries. Therefore, we will be your best partner for your pharmacology research. If you have any questions, please feel free to contact us.
1. Sonis S T. The pathobiology of mucositis. Nature Reviews Cancer. 2004, 4(4): 277-284.
2. Whittaker A L.; et al. The assessment of general well-being using spontaneous burrowing behaviour in a short-term model of chemotherapy-induced mucositis in the rat. Laboratory animals. 2015, 49(1): 30-39.