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Muscle Pain Models

Creative Animodel is dedicated to providing preclinical evaluation services of novel therapeutics in muscle pain models. With our experienced experts, we provide full assistance from project design to project executing, all the way until data analysis to advance your progress towards IND approval.

What Is Muscle Pain?

Muscle pain is one of the major clinical manifestation of most chronic conditions like low back pain, myositis, myofascial pain, and fibromyalgia. Unlike cutaneous pain, muscle pain results in a diffuse, aching pain. The most common causes are the overuse or over-stretching of a muscle or group of muscles. However, it can also be caused by diseases, disorders and medications. Besides, muscle pain is also a sign of acute rejection after heart transplant surgery.
Several clinical conditions are associated with muscle pain that may range in severity from an intermittent but recurring distraction, to a debilitating disorder lasting for months that is accompanied by severe stress and in some cases significant motor impairment. Medical treatment for chronic muscle pain can cost a lot of money and many people lost work productivity because of it. But what we know about the underlying mechanisms of muscle pain is relatively little.

Muscle Pain Models in Creative Animodel

Models of muscle pain that include inflammatory and non-inflammatory components are essential for studying mechanisms and potential treatments of muscle pain. With renewed interest in the subject, we have developed more refined and promising models for the investigating of muscle pain. Also those models are better parallels between human and animal models.

Carrageenan-induced model
Carrageenan is an extract of seaweed that causes localized inflammation when it is administered to various tissues and is used in some standard animal models of inflammatory pain as a pain-producing stimulus. This model uses bilateral intramuscular injections of carrageenan into the triceps muscles of animals to produce a localized inflammatory response. This model mimics a wide range of painful muscular disorders with an inflammatory component such as myositis and tendonitis. It provides the opportunity to test novel compounds for alleviation of chronic muscular inflammatory pain.

Acidic saline-induced model
In the acidic saline model, hyperalgesia occurs after the second injection of acid and remains for up to 4 weeks. There is no inflammation or tissue damage observed histologically at any time across the 4-week period. The hyperalgesia in this model is also bilateral. This method has an advantage over other inflammatory models as it can mimic conditions like fibromyalgia, where muscle pain is not associated with histopathological changes in the muscle.

Pharmacology Evaluation

Experimental animals for pain study need special consideration because of ethical issues. We have professional and experienced experts to handle those complicated technical and ethical problems, and help our clients reach research goals. Our assessments include, but are not limited to:
• Assessment of muscle nociception in anesthetized animals
• Behavioral assessment of muscle pain in a lightly anesthetized model
• Post-injection sensitization in a lightly anesthetized model
• Behavioral assessment in awake animals
• Grip force as a model for muscle hyperalgesia
• Bite force as a measure for craniofacial muscle hyperalgesia

Creative Animodel has a deep understanding of muscle pain. We can assess animal pain by activation of nociceptors, recruitment of central nociceptive pathways, and predictable nocifensive behaviors in animals. If you have any question, please feel free to contact us. We will work closely with you to obtain the most effective and meaningful data from muscle pain study using animal model.

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Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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