Neuropathic Pain Models
Creative Animodel is a professional Contract Research Organization providing pharmacological assays based on our disease models. With decades of experience and unparalleled platforms, our highly skilled scientists have successfully established neuropathic pain models to help our customers understand the mechanisms of neuropathic pain and develop safe and effective therapeutics. We are also glad to work with you to validate custom models to meet your preclinical research needs.
What Is Neuropathic Pain?
Neuropathic pain is caused by nerves damage or diseases affecting the somatosensory nervous system. It is characterized by the sensory abnormalities, such as unpleasant abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), as well as pain in response to a stimulus that does not normally provoke pain (allodynia). Neuropathic pain may result from disorders of the peripheral nervous system (PNS) or the central nervous system (CNS). Thus, it can be divided into peripheral neuropathic pain (PNP) and central neuropathic pain (CNP). PNP is developed after damage to a peripheral nerve fiber caused by trauma or diseases, while CNP is developed after damage to the central nervous system at any stage from the spinal cord to the cerebral cortex pain.
Neuropathic pain is often described as a lancinating or continuous burning pain. Up to 2% to 3% of the human population is suffered from this severe and persistent pain. However, the pharmacotherapy for neuropathic pain has had a limited success with little or no response to commonly used pain reducing drugs, such as NSAIDS and opiates. Consequently, there is a considerable need to explore novel treatment modalities.
Our Neuropathic Pain Models
With years of expertise, Creative Animodel has established several PNP models and CNP models by different strategies in various animal species. Our neuropathic pain models include but are not limited to those shown in table 1.
Table 1. PNP and CNP models provided by Creative Animodel
|PNP Models||CNP Models|
|• Neuroma Model|
• Peripheral Nerve Ligations Model
• Cryogenic Lesion Model
• Diabetic Neuropathy Model
|• Neurotoxicity-induced Spinal Cord Lesions Model|
• Laser-induced Spinal Cord Lesions Model
Creative Animodel is dedicated to preclinical efficacy evaluation of novel therapeutics in neuropathic pain models. Our company has the top scientists and the most advanced experimental platforms to provide the most comprehensive and satisfactory services for our global clients. We guarantee our clients to efficiently advance their drug development programs with a greater degree of certainty at a fraction of the cost and time compared to current development paradigms.