Obesity is defined as being more than 20% (in men) or 25% (in women) overweight. The World Health Organization (WHO) estimates that 10 % of the world’s adult population was obese. Obesity is increasing rapidly throughout the developed world and has increased from 13% to 31% in the US in the past 30 years. Meanwhile the global incidence of obesity is continuing to rise. Currently, scientists already made a huge effort to minimize the negative effects of obesity and decrease its overall prevalence throughout the world.
Obesity is a globally widespread disease. The primary causes of obesity are excessive calorie intake and lack of physical activity. Obesity is also a major risk factor for cardiovascular disease, diabetes, stroke, certain cancers, osteoarthritis, gastrointestinal, reproductive disorders and pulmonary diseases. The incidence of obesity continues to climb, making it imperative that animal models sharing characteristics of human obesity and its co-morbidities be developed in the quest for novel preventions and treatments.
Fig 1. A brief system for the obesity models. (Maruvada P. et al, 2017).
Creative Animodel provides various in vivo animal models and in vitro cell culture models to investigate the mechanism of obesity and novel therapeutics to treat human obesity (Figure 1). With Creative Animodel, you get more than a highly qualified CRO, you gain a partner, who understands and has the experience to design, validate and execute all preclinical program requirements.
Obesity Models Services at Creative Animodel
Creative Animodel offers a complete suite of animal models and services for the evaluation of novel therapeutics. We are dedicated to providing our customers with the most suitable animal models of obesity to advance the development of potential therapeutics in clinical studies. We will work closely with you on every step for obtaining meaningful and suggesting data from animal model studies for obesity. Although none of the models can completely capture the complexity of human metabolic syndrome, each model mimics certain aspects of the disease. Our featured animal models include, but are not limited to:
• Non-human primates: DIO (diet-induced obesity) rhesus macaques & DIO cynomolgus macaques
• High fat diet mouse/rat
• DIO mouse/rat
• Age-related obesity in mice
• Transgenic (monogenic and polygenic) mouse/rat
• Mini-pig model
Our studies of obesity are mainly divided into four types:
• Energy expenditure test of obesity
• Body composition analysis of obesity
• Dietary-induced obese animal
• Genetic obese animals
Our preclinical platforms and services include, but are not limited to:
• Feed intake measurement
• Body weight measurement
• Insulin levels measurement
• Glucose tolerance testing
• Blood glucose and blood pressure measurement
• Analysis of serum lipoproteins
• Magnetic resonance spectroscopy (MRS)
• Dual energy X-ray analysis (DEXA)
• Contrast-enhanced ultrasound (CEU)
• Hands-on experience with a large variety of animal metabolic models
• General technical report (GTR) generation for IND filing
• Excellent technical and surgical capability
• Gold-standard methods and novel in-house techniques
• Dedicated research platform to evaluate the therapeutic potential of your compounds
• Customized research solutions to target your needs
Creative Animodel has a scientific team with extensive experience in anti-obesity drug and treatment development. We can assist you with study design, animal model selection, experiment conduct, data analysis and report writing. If you have any other questions, please feel free to contact us. We look forward to working with you in the near future.
1. Maruvada, P.; et al. The human microbiome and obesity: moving beyond associations. Cell Host Microbe. 2017, 22(5): 589-599.