The skeleton mechanically supports our stature and locomotion, protects our vital organs, and controls mineral homeostasis. However, a wide spectrum of factors, including genetic backgrounds, diseases and disorders, age, menopause-associated hormonal changes, repetitive use of the joint, and injury or trauma, can result in diverse orthopedic disorders in humans. Most people will during a lifetime experience a degenerative joint disease (e.g., osteoarthritis) or a bone fracture.
Animal Models of Orthopedics at Creative Animodel
We provide the following animal models of orthopedics and preclinical studies to improve the understanding of orthopedic research and the treatment of the diseases and disorders.
Cartilage Repair Models
Damaged or deteriorated articular cartilage leads to joint pain and restricted movement and pain. We establish diverse cartilage repair models by surgical techniques to support basic research and drug discovery and development. Our disease model species include rats, rabbits, dogs, sheep, goats, and horses.Bone Metastases Models
Bone metastases can cause osteolytic or osteoblastic metastases that result in pain, pathologic fractures, and mortality. We employ in vivo injection techniques to induce bone metastasis in rodents, dogs, cats, and non-human primates. Osteoarthritis Models
Osteoarthritis (OA) is a complex disease process involving the whole synovial joint, affecting millions of people worldwide. We provide a wide spectrum of models to settle for your specific research of osteoarthritis and associated joint pain. Osteoporosis Models
Osteoporosis is a common skeletal disorder characterized by decreased bone miner content and changed bone structure readily leading to bone fragility and fractures. We provide both primary and secondary osteoporosis models for basic research and drug assessments.Bone Repair Models
Bone repair is vital for people who suffer bone injury or trauma, or experience a loss of bone caused by a disease. We provide in vivo models of normal fracture, delayed union, nonunion, segmental defects to assist you in improving the treatment for bone repair.Juvenile Bone Growth Models
Bone safety (health) is affected by several factors, such as genetic backgrounds, age, diseases, medication, hormonal changes, and lifestyle. We provide diverse preclinical models for studies of pathology and treatment efficacy on juvenile bone growth, such as Sprague-Dawley weanling rats.
Creative Animodel has spent decades of efforts providing specialty pharmacology services based on our animal models of human diseases. Our state-of-the-art facilities and profound pharmaceutical knowledge enhance our capabilities to optimize and exploit disease models to advance the pharmaceutical industries.
Xu, F.; Mcdonald, J.M. Disorders of Bone Remodeling. Annual Review of Pathology. 2011, 6(1):121.