Creative Animodel provides a broad range of laboratory services and consultancy to assess the efficacy, safety and exposition of drug candidates on preclinical pharmacological models. Various animal models of otology disease are available, such as hearing loss models, otitis media models, tinnitus models, and Ménière's disease models. Partnering with Creative Animodel will enable you to gain the most benefits for your drug discovery and development.
Commonly used animal species including mice, rats, rabbits, pigs, cats, etc., are all available in Creative Animodel. According to your specific needs, we can establish disease models by external stimulation, spontaneously induction, or genetic modification. We use these models to assess your drug candidates by a series of in vivo trials. Our otology disease models are shown below.
Hearing Loss Models
Hearing loss is a prevalent sensory disorder that does not have treatment. In adult mammals, the death of auditory hair cells caused by noise exposure, aging, and medications is irreversible and can lead to deafness. The underlying fundamental knowledge of hearing loss is severely lacking. Creative Animodel can conduct different services by providing several types of animal models, such as noise-induced hearing loss models, age-related hearing loss models, and drug-induced hearing loss models.
Otitis Media Models
Otitis media is defined as inflammation of the middle ear, including the auditory ossicles and the Eustachian tube. The causes of otitis media include infectious, anatomic/physiologic, host, and environmental factors. Our company offers several strategies to establish otitis media models. Eustachian tube ligation or cauterization, chemical materials injection through the tympanic membrane, as well as genetic modification are available to meet your different needs.
Tinnitus is the perception of a sound without external stimulation. It is often described as a ringing, or buzzing in the ears or the head. Tinnitus has many causes including noise exposure, physical injury, and central auditory system changes. Mimicking this human disorder, tinnitus can be induced in rodents by acoustic trauma or chemical agents (e.g. salicylate) allowing preclinical studies.
Ménière's Disease Models
Ménière's disease (MD) is a disorder of the inner ear that causes vertigo attacks, fluctuating hearing loss, tinnitus and aural fullness. The aetiological factors of MD are complicated. A characteristic sign of MD is endolymphatic hydrops (EH), a disorder in which excessive endolymph accumulates in the inner ear and causes damage to the ganglion cells. Murine models for Ménière's disease are provided by treatment with lipopolysaccharide (LPS) and aldosterone, or with saline and vasopressin receptor 2.
Benefiting from strong expertise and industrial background as well as an international network of clients and partners, Creative Animodel offers a comprehensive range of studies to support fully integrated drug discovery collaboration or standalone service for your internal projects. If you have any need, please don’t hesitate to contact us.