Creative Animodel has a long history of experience in all aspects of pain research and has successful established various of professional pain animal models. We conduct preclinical in vivo tests for pain disorders for both efficacy and side-effect profiling. To meet the needs of your specific drug discovery project we also have the flexibility and expertise to develop custom in vivo models.
Pain, both acute and chronic, remains a significant health problem despite tremendous progress in understanding its basic mechanisms. It is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. According to the report, more than 100 million Americans experience chronic pain associated with heart disease, cancer, and diabetes. Furthermore, pain costs the United States half a trillion dollars annually, measured in terms of health care usage, lost wages, and impact on quality of life. Despite the prevalence and impact of pain, it is extremely difficult to treat, and few basic science advances have been effectively translated to the clinical setting over the last several decades.
In the clinical setting, pain may be refractory to pharmaceutical interventions. Besides, patients may refuse to take pain medication because of adverse side effects. It is imperative to develop novel pharmaceutical agents and therapeutic methods that specifically target these painful conditions. Animal models have been crucial in our understanding of pain from a variety of disease states, both acute and chronic. At Creative Animodel, various pain models have been developed. These models directly mimic a clinical condition and have been useful in screening analgesics and understanding analgesic profiles.
Inflammatory pain, caused by inflammatory reaction, is often associated with penetration wounds, burns, extreme cold, fractures, arthritis, autoimmune conditions, excessive stretching, infections and vasoconstriction. Creative Animodel provides inflammatory pain models induced by formalin, carrageenan and adjuvant.
Neuropathic pain is often described as a lancinating or continuous burning pain, which is caused by nerves damage or diseases affecting the somatosensory nervous system. Both peripheral nervous pain (PNP) and central neuropathic pain (CNP) models are available.
Muscle pain is one of the major clinical manifestation in most chronic conditions like low back pain, myositis, myofascial pain, and fibromyalgia. Creative Animodel establishes both inflammatory and non-inflammatory muscle pain models to help you advance your drug progress.
Osteoarthritis pain occurs when the cartilage is lost and boney spur formations are allowed to touch adjacent bones, causing significant inflammation and pain. We provide spontaneous models, chemistry-induced models and physically-induced models to help you understand the mechanisms underlying osteoarthritis pain and develop novel treatments.
Visceral pain is the pain associated with a wide variety of disorders of internal organs, like gallstones, acute pancreatitis, interstitial cystitis/bladder pain syndrome, and male chronic pelvic pain syndrome. We provide both chemical and distension induced visceral pain models to promote your drug development.
Creative Animodel is dedicated to offering integrated preclinical evaluation services of pharmacology and toxicology for your drug candidates. Our in-house scientists have a deep understanding of pain mechanisms, which is extremely important toward effective translation from clinic to basic science, and from basic science to clinic. Through our strict supervisory and regulatory systems, we can ensure accuracy and high-quality reports. If you have any questions, please feel free to contact us at any time.