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Respiratory Disease

The respiratory system plays a key role in oxygen delivery to fuel for all the body's functions, and is also important in waste elimination, temperature regulation and blood pH balance. Respiratory diseases affect the upper respiratory tract and can arise from numerous causes either directly or indirectly, such as infections, smoking, inhalation of toxic agents, accidents and genetic factors. Respiratory diseases may lead to difficulty breathing, cough, emphysema and other conditions. Left untreated, respiratory diseases can result in chronic issues like asthma, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis, and become potentially life threatening.

The challenging and competitive respiratory drug development landscape is facing challenges throughout the discovery and development process. Creative Animodel has a long history of experience with all aspects of respiratory therapy research and has successfully established a series of professional animal models for both acute and chronic respiratory conditions.

Asthma is a chronic inflammatory disease involving the airways in the lungs, which causes recurring episodes of wheezing, chest tightness, breathlessness, and coughing. Asthma models are induced by OVA or house dust mite.

Cough is an extremely common feature of many respiratory diseases, which affects nearly 10% of the general population. Both cough and exacerbated cough models are available.

Allergic rhinitis
Allergic rhinitis (AR) is a type of inflammation in the nose which occurs when the immune system overreacts to allergens in the air. Well-established allergen directly induced AR model and IgE-deficient mice are provided for global clients.

Lung Inflammation
Lung inflammation is the basis for the majority of both acute and ongoing lung conditions. Creative Animodel establishes lung inflammation models induced by LPS or tobacco smoke.

Pulmonary Fibrosis
Pulmonary fibrosis is a chronic and irreversible respiratory disease where the scars are formed in the lung tissue. We provide bleomycin-induced pulmonary fibrosis, which is a useful pre-clinical model of human lung fibrosis.

Acute Lung Injury Models
Acute Lung Injury (ALI) is characterized by neutrophilic inflammation of the lung and decrease of lung compliance that can result in severe pulmonary edema leading to impaired pulmonary gas exchange. ALI models are induced by LPS, acid aspiration, hyperoxia or oleic acid.

Creative Animodel offers proof-of-principle pharmacology services in pre-clinical models of human diseases to assist evaluations of efficacy and safety to further achieve success in the clinical trials. We provide support in all aspects from model selection, assay performing, data delivery, personal contact, as well as new model establishment to meet the specific needs of a particular compound or discovery program. We sincerely look forward to working with global researchers to assist their cutting-edge projects with our professional service.

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