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RSV Infection Models

Creative Animodel, as a leading biological contract research organization, offers different kinds of professional services for our global clients. With years of experience, our experts have established respiratory syncytial virus (RSV) infection models to help our customers elucidate the mechanisms of RSV natural infection, understand the process of vaccine-enhanced disease and develop safe & effective vaccines.

Overview of RSV Infection

RSV is a member of the family Paramyxoviridae and subfamily Pneumovirinae, and has a nonsegmented negative stranded genome of 15,222 nucleotides. Virions consist of nucleocapsid with a lipid envelope, and are irregular in size and shape. There are two major glycoproteins expressed on virion surface: the fusion protein and the attachment protein. For human infants, RSV causes both upper and lower respiratory tract infection with an incubation time ranging from 2 to 8 days.

Most children are infected during their first RSV season; and by 2 years of age, almost all children have been infected with RSV and over 50% of them have been infected twice. The global burden of this disease is estimated at 64 million cases and 160,000 deaths annually. Importantly, long-term resistance to RSV infection does not develop and reinfection is common which often causes severe illness among those with chronic lung or heart disease.

Despite the considerable worldwide impact of RSV infection, a vaccine to protect against RSV remains elusive. There is also a need for safe and efficacious therapeutics against RSV infection. Studies are not feasible in humans because of safety issues; consequently, several animal models have been established to better understand the mechanisms by which RSV causes disease.

Our RSV Infection Models

With years of expertise, Creative Animodel has established RSV infection models to help our customers elucidate the mechanisms of RSV natural infection, understand the process of vaccine-enhanced disease and develop safe & effective drugs. Our RSV infection models include mouse nasal infection model and cotton rat model.

• Mouse Nasal Infection Model
BALB/c mice have been widely used to study lower respiratory tract infection by RSV inoculation, but titers from mouse nasal cavities are generally very low, on the order of 100 to 1,000 PFU/nose. Our method allows the inoculum to be absorbed by the nasal mucosa rather than being delivered through the nose into the trachea and esophagus. Mouse nasal infection models will provide useful and relevant in vivo systems to assay both the pathogenesis of host immun and the relative efficacy of potential RSV vaccine candidates.

• Cotton Rat Model
Cotton rats are developed as an RSV model because they are highly susceptible to RSV and permissive to RSV replication. Respiratory syncytial virus infection in cotton rats induces pulmonary histopathology similar to that observed in humans, although it does not cause overt clinical symptoms. Infected animals develop prominent epithelial degeneration of nasal mucosa, discernable peribronchiolitis, perivasculitis and interstitial pneumonitis. Our cotton rats model can be used to study the efficacy of antiviral drugs and prophylaxis reagents.

Creative Animodel has considerable experience in executing models of RSV infections disease. As your partner, our mission is to deliver high-quality image and reliable data accurately and efficiently to further optimize your drug development process. We look forward to working with you in the future.

Reference:
1. Cormier S A,; et al. The use of a neonatal mouse model to study respiratory syncytial virus infections. Expert review of anti-infective therapy. 2010, 8(12):1371-80.

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