Systemic Lupus Erythematosus Models
As a professional contract research organization (CRO), Creative Animodel is specialized in establishing disease models and conducting in vivo assays for new drug research and development. Our company provides various animal models of systemic lupus erythematosus to meet your specific needs.
What Is Systemic Lupus Erythematosus?
Systemic lupus erythematosus (SLE), also simply known as lupus, is a chronic autoimmune disorder, which may affect the skin, joints, kidneys, and other organs. Common symptoms of SLE include a red rash, painful and swollen joints, mouth ulcers, hair loss, chest pain and so on. Often there are periods of illness and remission during the course of disease. Female sex hormones releasing, vitamin D deficiency, smoking, sunlight, and certain infections are believed to increase the incidence of SLE. The mechanism of SLE involves an auto-immunoreaction mediated by autoantibodies. These antinuclear antibodies (ANA) can result in inflammation and attack of a person’s own tissue. ANA testing and anti-extractable nuclear antigen (anti-ENA) testing are widely used in the diagnosis of SLE.
Figure 1. Common symptoms of SLE
Rate of SLE varies among countries from 200 to 700 per million. Women of African, Chinese, and Caribbean descent are at higher risk than men and white people. At present, there is no cure for SLE. Non-steroidal anti-inflammatory drugs, immunosuppressants, corticosteroids, methotrexate, and hydroxychloroquine are frequently used to relieve the symptoms of the disease.
SLE Models at Creative Animodel
• SLE in NZB/W F1 mice
Creative Animodel provides the classical NZB/W F1 model of lupus generated by the F1 hybrid between the NZB and NZW strains. Both NZB and NZW display limited autoimmunity, while NZB/W F1 hybrids develop severe lupus-like phenotypes comparable to those of lupus patients. These lupus-like phenotypes include lymphadenopathy, splenomegaly, elevated serum antinuclear autoantibodies and immune complex-mediated glomerulonephritis (GN) that becomes apparent at 5-6 months of age, leading to kidney failure and death at 10-12 months of age.
• SLE in MRL/lpr mice
Attributed to a recessive autosomal mutation termed lymphoproliferation (lpr), the MRL/lpr substrain has high concentrations of circulating immunoglobulins, resulting in large amounts of immune complexes. In addition, the MRL/lpr substrain, which has developed an SLE-like phenotype characterized by lymphadenopathy, displays an accelerated mortality rate.
• TMPD-induced lupus in murine
Tetra-methylpentadecane (TMPD), commonly known as pristane, is the most active component of mineral oil, and TMPD-induced lupus is a murine model of SLE. Symptoms of TMPD-induced lupus include arthritis, immune complex-mediated glomerulonephritis, pulmonary capillaritis, inflammation of the pericardium and pleura, as well as the presence of autoantibodies. This model is well suited for examining links between dysregulated type I interferon (IFN-I) production and the pathogenesis of human SLE, which like TMPD-lupus, is associated with high levels of IFN-I.
Creative Animodel is a leading biotech company in the field of pharmaceutical industry. Our abundant animal models, advanced technology platforms, professional assays and experienced experts can help accelerate the development of your projects. If you have any questions, please don’t hesitate to contact us. We look forward to establishing cooperative relationships with you in the near future.
1. Perry, Daniel; et al. Murine models of systemic lupus erythematosus. BioMed Research International.2011, Feb.14.
2. Hau, Jann. and Steven J. Schapiro, eds. Handbook of laboratory animal science: essential principles and practices. Vol. 3. CRC press, 2002.