Creative Animodel, as a preclinical Contract Research Organization (CRO), has spent decades of efforts to provide professional toxicology services for new drug and biologics. With high-level scientific expertise and specialized resources, we provide dermatotoxicology assays to help test cytotoxic effects of substances on human skin.
What Is Dermatotoxicology?
The increased recognition and interest in skin as a target organ and route of entry for potentially toxic compounds has fueled rapid growth in the field of dermatotoxicology over the years. Many subspecialties of dermatotoxicology exist and are derived from principles of basic scientific disciplines. Dermatotoxicology, as a branch of toxicology, deals with adverse effects of chemicals on skin, hair and nails. Dermatotoxicology includes the study of dermal penetration, the evaluation of topically applied chemicals and those chemicals’ ability to directly irritate or damage the skin, or to promote the development of neoplasias.
There is a growing demand for methods of testing cytotoxic effects of substances on human skin. The cellular response in human skin to topically administered substances is a complex process and investigation of this physiological process is dependent on the use of standardized models. Several in vivo models have been used to study the effects of different substances when they are applied to the skin. However, human skin in vivo is variable and difficult to be sampled. Additionally, animal experiment is desirable from an ethical standpoint. So there is a demand for a well-controlled in vitro model that provides a large number or standardized samples and resembles the in vivo situation as closely as possible.
Our Dermatotoxicology Services
Creative Animodel provides a variety of appropriate in vitro dermatotoxicology methods for guaranteeing the drug safety. Our alternative dermatotoxicology services include:
• Epidermal cell toxicity assay
• In vitro cell migration assay
• In vitro angiogenesis assay
• Released cytokines quantification assay
• Oxidative stress assay
• Antagonistic/agonistic properties assay
• Intracellular calcium mobilization assay
• Biomarkers expression assay
Our Advantages of Dermatotoxicology Services
• Wide ranges of detection technologies
• Multi-mode microplate analysis systems
• Advanced high-content screening equipment
• Evaluation of a wide range of markers and cellular features
Creative Animodel performs a variety of in vitro toxicity tests and assays under strict GLP and GMP compliance with FDA and EPA guidelines. With state-of-the-art facilities and profound pharmaceutical knowledge, we are capable to proceed with cell-based functional assays to support pharmaceutical product development. We look forward to collaborating with you in the near future.
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