Creative Animodel is an international contract research organization specialized in providing services of preclinical drug evaluation. Our services are involved in drug metabolism and pharmacokinetics, animal model generation, in vivo and in vitro pharmacology and toxicology. Creative Animodel has established global business to help our clients accelerate projects of drug research and development.
Overview of Drug-Drug Interactions
When two or more drugs are used together, the pharmacological result is not necessarily the sum of the effects obtainable from the drugs used individually in the same doses. This is because one drug may affect the action of another, and this is termed drug-drug interactions (DDI). There are many mechanisms of drug interactions. Some are chemical, some are biochemical, and some are physiological/pharmacological. Many of the most easily understood drug interactions are mediated by drug-induced changes in drug absorption, distribution, metabolism, and excretion. Certain drug interactions are of great clinical importance, usually involving a drug with a narrow therapeutic window.
The induction and inhibition of drug metabolic enzymes are two common types of metabolic drug-drug interactions. Decreased or increased drug exposures can be caused by these interactions. For example, cytochrome P450 (CYP450) induction may reduce the plasma levels of co-administered drugs, resulting in increased formation of toxic metabolite or decreased efficacy. Conversely, CYP450 inhibition may increase the plasma levels of drugs leading to toxicity. In addition, significant changes in total or local drug exposures are also caused by inhibition of drug transporters due to a new chemical entity of co-medicated drugs.
DDI Services at Creative Animodel
• Metabolism services
Creative Animodel provides metabolism services, such as CYP450 induction and inhibition, UGT induction and inhibition, and time dependent inhibition, to evaluate the drug-drug interactions.
• Absorption/distribution/transporter services
Creative Animodel provides various permeability and transporter assays to evaluate your drug candidate. Our services include cell or tissue permeability assays, transporter inhibition, substrate identification and so on.
• A comprehensive range of services
• Cutting-edge technology platforms
• Experienced and skilled scientists
• Rapid turnaround with favorable price
Creative Animodel provides a wide range of in vitro drug-drug interaction assays to help our clients screen compounds. High-quality and repeatable data are guaranteed based on our professional staff and advanced equipment. If you have any specific needs, please don’t hesitate to contact us.
1. Curry, S.H. & Whelpton R. Drug Disposition and Pharmacokinetics: From Principles to Applications. 2010.